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MNN1 alpha-1,3-mannosyltransferase MNN1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856718, updated on 4-Jan-2025

Summary

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Official Symbol
MNN1
Official Full Name
alpha-1,3-mannosyltransferase MNN1
Primary source
SGD:S000000803
Locus tag
YER001W
See related
AllianceGenome:SGD:S000000803; FungiDB:YER001W; VEuPathDB:YER001W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables alpha-1,3-mannosyltransferase activity. Involved in N-glycan processing and protein O-linked glycosylation. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See MNN1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (153520..155808)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene dolichyl-diphosphooligosaccharide-protein glycotransferase Neighboring gene Irc22p Neighboring gene Nop16p Neighboring gene mannose-6-phosphate isomerase PMI40

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sorting of yeast alpha 1,3 mannosyltransferase is mediated by a lumenal domain interaction, and a transmembrane domain signal that can confer clathrin-dependent Golgi localization to a secreted protein. Graham TR, et al. Mol Biol Cell, 1995 Jul. PMID 7579696, Free PMC Article
  2. Clathrin-dependent localization of alpha 1,3 mannosyltransferase to the Golgi complex of Saccharomyces cerevisiae. Graham TR, et al. J Cell Biol, 1994 Nov. PMID 7962051, Free PMC Article
  3. Cloning and analysis of the Saccharomyces cerevisiae MNN9 and MNN1 genes required for complex glycosylation of secreted proteins. Yip CL, et al. Proc Natl Acad Sci U S A, 1994 Mar 29. PMID 8146181, Free PMC Article
  4. Monitoring of the tissue distribution of fibroblast growth factor containing a high mannose-type sugar chain produced in mutant yeast. Takamatsu S, et al. Glycoconj J, 2004. PMID 15238703
  5. Biosynthesis of yeast mannoproteins. Synthesis of mannan outer chain and of dolichol derivatives. Parodi AJ. J Biol Chem, 1979 Sep 10. PMID 381304

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ybl006c (Rsc14) controls expression of MNN6, MNN4 and MNN1
    Title: Rsc14-controlled expression of MNN6, MNN4 and MNN1 regulates mannosylphosphorylation of Saccharomyces cerevisiae cell wall mannoproteins.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables alpha-1,3-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-1,3-mannosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-glycan processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-1,3-mannosyltransferase MNN1
NP_010916.1
  • Alpha-1,3-mannosyltransferase; integral membrane glycoprotein of Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides; one of five S. cerevisiae proteins of MNN1 family; targeted to vacuole via AP-3 pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    153520..155808
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178892.1 → NP_010916.1  TPA: alpha-1,3-mannosyltransferase MNN1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010916.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLP7, P39106
    UniProtKB/TrEMBL
    N1P5F1
    Conserved Domains (1) summary
    pfam11051
    Location:317 → 613
    Mannosyl_trans3; Mannosyltransferase putative
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39106.1

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