IMP3 snoRNA-binding rRNA-processing protein IMP3 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: IMP3
Official Full Name: snoRNA-binding rRNA-processing protein IMP3
Primary source: SGD:S000001191
Locus tag: YHR148W
See related: AllianceGenome:SGD:S000001191; FungiDB:YHR148W; VEuPathDB:YHR148W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables snoRNA binding activity. Involved in rRNA processing and ribosomal small subunit biogenesis. Part of Mpp10 complex and small-subunit processome. Orthologous to human IMP3 (IMP U3 small nucleolar ribonucleoprotein 3). [provided by Alliance of Genome Resources, Jan 2025]
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Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

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The Imp3 in complex with an Mpp10 peptide involved in yeast ribosome biogenesis have been purified and crystallized.
Title: Purification, crystallization and preliminary X-ray diffraction analysis of Imp3 in complex with an Mpp10 peptide involved in yeast ribosome biogenesis.
the Saccharomyces cerevisiae Imp3 protein is involved in DNA repair and telomere length control
Title: A viable hypomorphic allele of the essential IMP3 gene reveals novel protein functions in Saccharomyces cerevisiae.
Imp3p and Imp4p may help the small subunit processome to dock onto the pre-rRNA, an event indispensable for ribosome biogenesis and hence for cell growth
Title: Imp3p and Imp4p mediate formation of essential U3-precursor rRNA (pre-rRNA) duplexes, possibly to recruit the small subunit processome to the pre-rRNA.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables rRNA binding	IEA Inferred from Electronic Annotation more info
enables snoRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables snoRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in rRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA processing	IDA Inferred from Direct Assay more info	PubMed
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in ribosomal small subunit biogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal small subunit biogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of 90S preribosome	HDA more info	PubMed
part_of Mpp10 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Mpp10 complex	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membraneless organelle	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	IDA Inferred from Direct Assay more info	PubMed
part_of small-subunit processome	IMP Inferred from Mutant Phenotype more info	PubMed

NP_012018.1

Component of the SSU processome; SSU processome is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA

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The following sections contain reference sequences that belong to a specific genome build. Explain