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TDA3 Tda3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856400, updated on 4-Jan-2025

Summary

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Official Symbol
TDA3
Official Full Name
Tda3p
Primary source
SGD:S000001051
Locus tag
YHR009C
See related
AllianceGenome:SGD:S000001051; FungiDB:YHR009C; VEuPathDB:YHR009C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
BTN3
Summary
Predicted to enable oxidoreductase activity. Involved in retrograde transport, endosome to Golgi. Located in late endosome. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See TDA3 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (124109..125680, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene superoxide dismutase SOD2 Neighboring gene ribosomal 60S subunit protein L27A Neighboring gene putative serine--tRNA ligase DIA4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Btn3 is a negative regulator of Btn2-mediated endosomal protein trafficking and prion curing in yeast. Kanneganti V, et al. Mol Biol Cell, 2011 May 15. PMID 21441304, Free PMC Article
  2. Engineering the protein secretory pathway of Saccharomyces cerevisiae enables improved protein production. Huang M, et al. Proc Natl Acad Sci U S A, 2018 Nov 20. PMID 30397111, Free PMC Article
  3. MRC1-dependent scaling of the budding yeast DNA replication timing program. Koren A, et al. Genome Res, 2010 Jun. PMID 20219942, Free PMC Article
  4. RNAi expression tuning, microfluidic screening, and genome recombineering for improved protein production in Saccharomyces cerevisiae. Wang G, et al. Proc Natl Acad Sci U S A, 2019 May 7. PMID 31000602, Free PMC Article
  5. Retromer and the dynamin Vps1 cooperate in the retrieval of transmembrane proteins from vacuoles. Arlt H, et al. J Cell Sci, 2015 Feb 15. PMID 25512334

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Btn3 regulates the sorting function of two adaptors for SNARE proteins, the epsin Ent3 and the Batten-disease-linked protein Btn2.
    Title: Btn3 regulates the endosomal sorting function of the yeast Ent3 epsin, an adaptor for SNARE proteins.
  2. Btn3 is a negative regulator of Btn2-mediated endosomal protein trafficking and prion curing in yeast. [Btn3]
    Title: Btn3 is a negative regulator of Btn2-mediated endosomal protein trafficking and prion curing in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrograde transport, endosome to Golgi IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in late endosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tda3p
NP_011873.1
  • Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    124109..125680 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179139.1 → NP_011873.1  TPA: Tda3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011873.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKV4, P38758
    UniProtKB/TrEMBL
    A6ZSR3, B3LSD0
    Conserved Domains (1) summary
    COG0665
    Location:251 → 516
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38758.2

Gene LinkOut

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