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OSH7 oxysterol-binding protein related protein OSH7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856389, updated on 4-Jan-2025

Summary

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Official Symbol
OSH7
Official Full Name
oxysterol-binding protein related protein OSH7
Primary source
SGD:S000001043
Locus tag
YHR001W
See related
AllianceGenome:SGD:S000001043; FungiDB:YHR001W; VEuPathDB:YHR001W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables lipid binding activity and sterol transfer activity. Involved in several processes, including late endosome to vacuole transport; maintenance of cell polarity; and piecemeal microautophagy of the nucleus. Located in cortical endoplasmic reticulum. Orthologous to several human genes including OSBPL8 (oxysterol binding protein like 8). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See OSH7 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (106055..107368)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene ESCRT-0 subunit protein HSE1 Neighboring gene ribosomal 60S subunit protein L14B Neighboring gene ubiquinol--cytochrome-c reductase subunit 10 Neighboring gene coenzyme A transporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A generic protocol for the purification and characterization of water-soluble complexes of affinity-tagged proteins and lipids. Maeda K, et al. Nat Protoc, 2014 Sep. PMID 25167057
  2. INTRACELLULAR TRANSPORT. Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate. Moser von Filseck J, et al. Science, 2015 Jul 24. PMID 26206936
  3. AAA ATPases regulate membrane association of yeast oxysterol binding proteins and sterol metabolism. Wang P, et al. EMBO J, 2005 Sep 7. PMID 16096648, Free PMC Article
  4. Osh6 requires Ist2 for localization to ER-PM contacts and efficient phosphatidylserine transport in budding yeast. D'Ambrosio JM, et al. J Cell Sci, 2020 Jun 4. PMID 32327560
  5. Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins. Maeda K, et al. Nature, 2013 Sep 12. PMID 23934110

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ist2 recruits the lipid transporters Osh6/7 to ER-PM contacts to maintain phospholipid metabolism.
    Title: Ist2 recruits the lipid transporters Osh6/7 to ER-PM contacts to maintain phospholipid metabolism.
  2. Osh5-Osh7 bind cholesterol in vitro.
    Title: Oxysterol-binding protein homologs mediate sterol transport from the endoplasmic reticulum to mitochondria in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables lipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables sterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sterol transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sterol transfer activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in exocytosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in late endosome to vacuole transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maintenance of cell polarity IEA
Inferred from Electronic Annotation
more info
  
involved_in maintenance of cell polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in piecemeal microautophagy of the nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in piecemeal microautophagy of the nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sterol metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sterol transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cortical endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cortical endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
oxysterol-binding protein related protein OSH7
NP_011863.1
  • Oxysterol-binding phosphatidylserine transferase; part of family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; OSH7 has a paralog, OSH6, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    106055..107368
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179131.1 → NP_011863.1  TPA: oxysterol-binding protein related protein OSH7 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011863.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKR7, P38755
    UniProtKB/TrEMBL
    A6ZSQ2, B3LSB8, C7GMR2, C8ZA66, N1P9K1
    Conserved Domains (1) summary
    pfam01237
    Location:53 → 393
    Oxysterol_BP; Oxysterol-binding protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38755.1

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