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APM2 Apm2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856367, updated on 4-Jan-2025

Summary

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Official Symbol
APM2
Official Full Name
Apm2p
Primary source
SGD:S000001011
Locus tag
YHL019C
See related
AllianceGenome:SGD:S000001011; FungiDB:YHL019C; VEuPathDB:YHL019C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable clathrin adaptor activity. Involved in Golgi to vacuole transport. Located in early endosome and trans-Golgi network. Orthologous to human STON1-GTF2A1L (STON1-GTF2A1L readthrough); STON1 (stonin 1); and STON2 (stonin 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See APM2 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (67731..69548, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Aim17p Neighboring gene transcriptional regulator OPI1 Neighboring gene 4a-hydroxytetrahydrobiopterin dehydratase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A late Golgi sorting function for Saccharomyces cerevisiae Apm1p, but not for Apm2p, a second yeast clathrin AP medium chain-related protein. Stepp JD, et al. Mol Biol Cell, 1995 Jan. PMID 7749194, Free PMC Article
  2. Fab1p and AP-1 are required for trafficking of endogenously ubiquitylated cargoes to the vacuole lumen in S. cerevisiae. Phelan JP, et al. J Cell Sci, 2006 Oct 15. PMID 17003107
  3. A simple and inexpensive quantitative technique for determining chemical sensitivity in Saccharomyces cerevisiae. Hung CW, et al. Sci Rep, 2018 Aug 9. PMID 30093662, Free PMC Article
  4. TagSmart: analysis and visualization for yeast mutant fitness data measured by tag microarrays. Kim C, et al. BMC Bioinformatics, 2007 Apr 18. PMID 17442117, Free PMC Article
  5. The alternate AP-1 adaptor subunit Apm2 interacts with the Mil1 regulatory protein and confers differential cargo sorting. Whitfield ST, et al. Mol Biol Cell, 2016 Feb 1. PMID 26658609, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mil1 is a predicted lipase that binds Apm2 but not Apm1 and contributes to its membrane recruitment.
    Title: The alternate AP-1 adaptor subunit Apm2 interacts with the Mil1 regulatory protein and confers differential cargo sorting.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in Golgi to vacuole transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in clathrin-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of membrane coat IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Apm2p
NP_011844.1
  • hypothetical protein; homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    67731..69548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179099.1 → NP_011844.1  TPA: Apm2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011844.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKR4, P38700
    UniProtKB/TrEMBL
    C7GIR7, G2WF47, N1P4X3
    Conserved Domains (2) summary
    cd09250
    Location:256 → 603
    AP-1_Mu1_Cterm; C-terminal domain of medium Mu1 subunit in clathrin-associated adaptor protein (AP) complex AP-1
    cd14828
    Location:3 → 138
    AP_Mu_N; AP complex subunit mu N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38700.1

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