U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

OPT2 Opt2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856324, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
OPT2
Official Full Name
Opt2p
Primary source
SGD:S000006398
Locus tag
YPR194C
See related
AllianceGenome:SGD:S000006398; FungiDB:YPR194C; VEuPathDB:YPR194C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables oligopeptide transmembrane transporter activity. Involved in several processes, including cell redox homeostasis; positive regulation of monopolar cell growth; and vacuole fusion, non-autophagic. Located in Golgi trans cisterna; peroxisome; and plasma membrane. [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See OPT2 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (924304..926937, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Aqy1p Neighboring gene histone acetyltransferase Neighboring gene uncharacterized protein Neighboring gene putative maltose-responsive transcription factor

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Opt2 mediates the exposure of phospholipids during cellular adaptation to altered lipid asymmetry. Yamauchi S, et al. J Cell Sci, 2015 Jan 1. PMID 25359886
  2. Noise reduction in genome-wide perturbation screens using linear mixed-effect models. Yu D, et al. Bioinformatics, 2011 Aug 15. PMID 21685046, Free PMC Article
  3. Hgt1p, a high affinity glutathione transporter from the yeast Saccharomyces cerevisiae. Bourbouloux A, et al. J Biol Chem, 2000 May 5. PMID 10788431
  4. Nutrient regulation of oligopeptide transport in Saccharomyces cerevisiae. Wiles AM, et al. Microbiology (Reading), 2006 Oct. PMID 17005992
  5. Novel role for the Saccharomyces cerevisiae oligopeptide transporter Opt2 in drug detoxification. Aouida M, et al. Biochem Cell Biol, 2009 Aug. PMID 19767828

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that Opt2 is a novel factor involved in cell homeostasis by regulating lipid asymmetry.
    Title: Opt2 mediates the exposure of phospholipids during cellular adaptation to altered lipid asymmetry.
  2. Authors show that budding yeast Opt2, a close homolog of the plasma membrane glutathione transporter Opt1, localizes to peroxisomes.
    Title: The yeast oligopeptide transporter Opt2 is localized to peroxisomes and affects glutathione redox homeostasis.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables oligopeptide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oligopeptide transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oligopeptide transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oligopeptide transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in oligopeptide transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptide transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of monopolar cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of phospholipid translocation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of vacuole organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vacuole fusion, non-autophagic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi trans cisterna IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fungal-type vacuole HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Opt2p
NP_015520.1
  • Oligopeptide transporter; localized to peroxisomes and affects glutathione redox homeostasis; also localizes to the plasma membrane (PM) and to the late Golgi, and has a role in maintenance of lipid asymmetry between the inner and outer leaflets of the PM; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles and in polarized cell growth

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    924304..926937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184291.1 → NP_015520.1  TPA: Opt2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015520.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W4J4, Q06593
    UniProtKB/TrEMBL
    A6ZX68, N1P2J1
    Conserved Domains (1) summary
    cl14607
    Location:141 → 839
    OPT; OPT oligopeptide transporter protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06593.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools