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AQY1 Aqy1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856322, updated on 4-Jan-2025

Summary

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Official Symbol
AQY1
Official Full Name
Aqy1p
Primary source
SGD:S000006396
Locus tag
YPR192W
See related
AllianceGenome:SGD:S000006396; FungiDB:YPR192W; VEuPathDB:YPR192W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables water channel activity. Involved in ascospore formation; transmembrane transport; and water transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Bothnian type palmoplantar keratoderma; cataract (multiple); nephrogenic diabetes insipidus (multiple); optic nerve disease (multiple); and transverse myelitis. Orthologous to several human genes including AQP1 (aquaporin 1 (Colton blood group)); AQP2 (aquaporin 2); and AQP6 (aquaporin 6). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See AQY1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (921860..922777)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase III subunit C82 Neighboring gene ubiquinol--cytochrome-c reductase subunit 2 Neighboring gene histone acetyltransferase Neighboring gene Opt2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Saccharomyces cerevisiae aquaporin Aqy1 is involved in sporulation. Sidoux-Walter F, et al. Proc Natl Acad Sci U S A, 2004 Dec 14. PMID 15583134, Free PMC Article
  2. Molecular and functional study of AQY1 from Saccharomyces cerevisiae: role of the C-terminal domain. Laizé V, et al. Biochem Biophys Res Commun, 1999 Apr 2. PMID 10092523
  3. Yeast aquaporin regulation by 4-hydroxynonenal is implicated in oxidative stress response. Rodrigues C, et al. IUBMB Life, 2017 May. PMID 28337841
  4. Subangstrom resolution X-ray structure details aquaporin-water interactions. Eriksson UK, et al. Science, 2013 Jun 14. PMID 23766328, Free PMC Article
  5. Aquaporins in Saccharomyces. Genetic and functional distinctions between laboratory and wild-type strains. Bonhivers M, et al. J Biol Chem, 1998 Oct 16. PMID 9765289

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AQY1 role in oxidative stress response and its regulation by 4-hydroxynonenal
    Title: Yeast aquaporin regulation by 4-hydroxynonenal is implicated in oxidative stress response.
  2. Several genomic signatures at AQY1 and/or AQY2 reveal low variation surrounding these loci within strains of the same haplotype, but high variation between strain groups
    Title: Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisiae populations.
  3. Studies show that by using CYS4 as a covariate and conducted both single- and combined-cross linkage mapping, AQY1 and MKT1 were found to have drug-specific and background-dependent effects.
    Title: A combined-cross analysis reveals genes with drug-specific and background-dependent effects on drug sensitivity in Saccharomyces cerevisiae.
  4. Aqy1 is developmentally controlled and may play a role in spore maturation, probably by allowing water outflow
    Title: The Saccharomyces cerevisiae aquaporin Aqy1 is involved in sporulation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables channel activity IEA
Inferred from Electronic Annotation
more info
  
enables water channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables water channel activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables water channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables water channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in ascospore formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in water transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Aqy1p
NP_015518.1
  • Spore-specific water channel; mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    921860..922777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184289.1 → NP_015518.1  TPA: Aqy1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015518.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W4J2, O74680, P0CD91, P53386
    UniProtKB/TrEMBL
    D3W789, D3W7A4, N1NW73
    Conserved Domains (1) summary
    TIGR00861
    Location:54 → 266
    MIP; MIP family channel proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CD91.1

Gene LinkOut

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