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RPL43A ribosomal 60S subunit protein L43A [ Saccharomyces cerevisiae S288C ]

Gene ID: 856156, updated on 5-Jan-2025

Summary

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Official Symbol
RPL43A
Official Full Name
ribosomal 60S subunit protein L43A
Primary source
SGD:S000006247
Locus tag
YPR043W
See related
AllianceGenome:SGD:S000006247; FungiDB:YPR043W; VEuPathDB:YPR043W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Part of cytosolic large ribosomal subunit. Orthologous to several human genes including RPL37A (ribosomal protein L37a). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See RPL43A in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
2
Sequence:
Chromosome: XVI; NC_001148.4 (654166..654847)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene translation initiation factor eIF5 Neighboring gene Puf2p Neighboring gene Thp3p Neighboring gene Mcm16p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional analysis of three adjacent open reading frames from the right arm of yeast chromosome XVI. Waśkiewicz-Staniorowska B, et al. Yeast, 1998 Aug. PMID 9730282
  2. The contribution of a zinc finger motif to the function of yeast ribosomal protein YL37a. Rivlin AA, et al. J Mol Biol, 1999 Dec 10. PMID 10588896
  3. The role of the zinc finger motif and of the residues at the amino terminus in the function of yeast ribosomal protein YL37a. Dresios J, et al. J Mol Biol, 2002 Feb 22. PMID 11866512
  4. The dedicated chaperones of eL43, Puf6 and Loc1 can also bind RPL43 mRNA and regulate the production of this ribosomal protein. Yueh LY, et al. J Biochem, 2022 Jan 7. PMID 34661244
  5. Analysis of subunit folding contribution of three yeast large ribosomal subunit proteins required for stabilisation and processing of intermediate nuclear rRNA precursors. Pöll G, et al. PLoS One, 2021. PMID 34813592, Free PMC Article

See all (101) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results found that Puf6 and Loc1 are critical to maintaining the stability of Rpl43. Mutation of any one protein results in blockages at similar steps during biogenesis. Puf6 and Loc1 could interact with nascent Rpl43 co-translationally via the N-terminus of Rpl43. Correct formation of the Puf6, Loc1, and Rpl43 ternary complex is required to properly proceed to the next step in 60S biogenesis.
    Title: Puf6 and Loc1 Are the Dedicated Chaperones of Ribosomal Protein Rpl43 in Saccharomyces cerevisiae.
  2. Puf6 and Loc1 facilitate Rpl43 loading and are sequentially released from 60S after incorporation of Rpl43 into ribosomes in yeast.
    Title: The Roles of Puf6 and Loc1 in 60S Biogenesis Are Interdependent, and Both Are Required for Efficient Accommodation of Rpl43.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome IC
Inferred by Curator
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal 60S subunit protein L43A
NP_015368.1
  • Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    654166..654847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184140.1 → NP_015368.1  TPA: ribosomal 60S subunit protein L43A [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015368.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWR3, P0CX25, P0CX26, P49631
    UniProtKB/TrEMBL
    A6ZQ50, B3LLA2, C8ZBP1, G2WH97
    Conserved Domains (1) summary
    PTZ00255
    Location:1 → 88
    PTZ00255; 60S ribosomal protein L37a; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CX25.1
P0CX26.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials