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CCL1 TFIIH complex kinase subunit CCL1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856136, updated on 4-Jan-2025

Summary

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Official Symbol
CCL1
Official Full Name
TFIIH complex kinase subunit CCL1
Primary source
SGD:S000006229
Locus tag
YPR025C
See related
AllianceGenome:SGD:S000006229; FungiDB:YPR025C; VEuPathDB:YPR025C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in positive regulation of autophagy and transcription by RNA polymerase II. Located in mitochondrion. Part of transcription factor TFIIK complex. Orthologous to human CCNH (cyclin H). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See CCL1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (613377..614558, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Eaf3p Neighboring gene i-AAA protease YME1 Neighboring gene alpha,alpha-trehalase ATH1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ccl1, a cyclin associated with protein kinase Kin28, controls the phosphorylation of RNA polymerase II largest subunit and mRNA transcription. Valay JG, et al. C R Acad Sci III, 1996 Mar. PMID 8761664
  2. The kin28 protein kinase is associated with a cyclin in Saccharomyces cerevisiae. Valay JG, et al. J Mol Biol, 1993 Nov 20. PMID 8230216
  3. Rig2, a RING finger protein that interacts with the Kin28/Ccl1 CTD kinase in yeast. Faye G, et al. Mol Gen Genet, 1997 Aug. PMID 9294030
  4. The Ccl1-Kin28 kinase complex regulates autophagy under nitrogen starvation. Zhu J, et al. J Cell Sci, 2016 Jan 1. PMID 26567215
  5. Structure of TFIIK for phosphorylation of CTD of RNA polymerase II. van Eeuwen T, et al. Sci Adv, 2021 Apr. PMID 33827808, Free PMC Article

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIH holo complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIIK complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIK complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIIK complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TFIIH complex kinase subunit CCL1
NP_015350.1
  • Cyclin partner of the cyclin-dependent kinase (CDK) Kin28p; regulates the activity of Kin28p, a TFIIH-associated carboxy-terminal domain (CTD) kinase that facilitates recruitment of mRNA 5'-capping and polyadenylation factors to the RNAPII holoenzyme complex, and has a minor role in RNAPII transcription; subunit of TFIIK, a TFIIH subassembly; human homolog CCNH allows growth of a yeast ccl1 temperature-sensitive mutant at restrictive temperature

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    613377..614558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184122.1 → NP_015350.1  TPA: TFIIH complex kinase subunit CCL1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015350.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W435, P37366
    UniProtKB/TrEMBL
    A6ZWR8, B3LL86, B5VTI3, C7GQB3, C8ZJ49
    Conserved Domains (1) summary
    TIGR00569
    Location:49 → 376
    ccl1; cyclin ccl1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P37366.1

Gene LinkOut

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