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AIM45 Aim45p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856112, updated on 4-Jan-2025

Summary

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Official Symbol
AIM45
Official Full Name
Aim45p
Primary source
SGD:S000006208
Locus tag
YPR004C
See related
AllianceGenome:SGD:S000006208; FungiDB:YPR004C; VEuPathDB:YPR004C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable electron transfer activity and flavin adenine dinucleotide binding activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase. Located in mitochondrion. Human ortholog(s) of this gene implicated in multiple acyl-CoA dehydrogenase deficiency. Orthologous to human ETFA (electron transfer flavoprotein subunit alpha). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See AIM45 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (564007..565041, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene tRNA-Phe Neighboring gene uncharacterized protein Neighboring gene Hal1p Neighboring gene methylisocitrate lyase ICL2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Saccharomyces cerevisiae Genes, AIM45, YGR207c/CIR1 and YOR356w/CIR2, Are Involved in Cellular Redox State Under Stress Conditions. Lopes J, et al. Open Microbiol J, 2010 Aug 17. PMID 21253464, Free PMC Article
  2. Flavin adenine dinucleotide rescues the phenotype of frataxin deficiency. Gonzalez-Cabo P, et al. PLoS One, 2010 Jan 25. PMID 20111601, Free PMC Article
  3. Frataxin interacts functionally with mitochondrial electron transport chain proteins. González-Cabo P, et al. Hum Mol Genet, 2005 Aug 1. PMID 15961414
  4. Assessing systems properties of yeast mitochondria through an interaction map of the organelle. Perocchi F, et al. PLoS Genet, 2006 Oct 20. PMID 17054397, Free PMC Article
  5. Yeast mitochondrial dehydrogenases are associated in a supramolecular complex. Grandier-Vazeille X, et al. Biochemistry, 2001 Aug 21. PMID 11502169

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables electron transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables electron transfer activity IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Aim45p
NP_015329.1
  • Putative ortholog of mammalian ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response; ETF-alpha is an electron transfer flavoprotein complex subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    564007..565041 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184101.1 → NP_015329.1  TPA: Aim45p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015329.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W415, Q12480
    UniProtKB/TrEMBL
    B3LL65, B5VTG4, C8ZJ29, N1NW01
    Conserved Domains (1) summary
    COG2025
    Location:23 → 343
    FixB; Electron transfer flavoprotein, alpha subunit [Energy production and conversion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12480.1

Gene LinkOut

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