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uncharacterized protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 856111, updated on 4-Jan-2025

Summary

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Official Full Name
uncharacterized protein
Primary source
SGD:S000006207
Locus tag
YPR003C
See related
AllianceGenome:SGD:S000006207; FungiDB:YPR003C; VEuPathDB:YPR003C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable sulfate transmembrane transporter activity. Predicted to be involved in sulfate transmembrane transport. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in several diseases, including Pendred Syndrome; autosomal recessive nonsyndromic deafness (multiple); bone disease (multiple); calcium oxalate nephrolithiasis; and diarrhea (multiple). Orthologous to several human genes including SLC26A2 (solute carrier family 26 member 2); SLC26A4 (solute carrier family 26 member 4); and SLC26A6 (solute carrier family 26 member 6). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (561504..563768, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene putative 2-methylcitrate dehydratase Neighboring gene tRNA-Phe Neighboring gene Aim45p Neighboring gene Hal1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cell cycle-specified fluctuation of nucleosome occupancy at gene promoters. Hogan GJ, et al. PLoS Genet, 2006 Sep 22. PMID 17002501, Free PMC Article
  2. Bayesian Markov Random Field analysis for protein function prediction based on network data. Kourmpetis YA, et al. PLoS One, 2010 Feb 24. PMID 20195360, Free PMC Article
  3. Target of rapamycin complex 2-dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics in Saccharomyces cerevisiae. Bourgoint C, et al. J Biol Chem, 2018 Aug 3. PMID 29895620, Free PMC Article
  4. The yeast vacuolar membrane proteome. Wiederhold E, et al. Mol Cell Proteomics, 2009 Feb. PMID 19001347
  5. Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome. Finch AJ, et al. Genes Dev, 2011 May 1. PMID 21536732, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables secondary active sulfate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in sulfate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
NP_015328.1
  • Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    561504..563768 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184100.1 → NP_015328.1  TPA: uncharacterized protein YPR003C [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015328.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W414, P53394
    UniProtKB/TrEMBL
    B3LL64, C7GV28, C8ZJ28, N1NXF2
    Conserved Domains (1) summary
    COG0659
    Location:99 → 732
    SUL1; Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53394.1

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