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PDH1 putative 2-methylcitrate dehydratase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856108, updated on 4-Jan-2025

Summary

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Official Symbol
PDH1
Official Full Name
putative 2-methylcitrate dehydratase
Primary source
SGD:S000006206
Locus tag
YPR002W
See related
AllianceGenome:SGD:S000006206; FungiDB:YPR002W; VEuPathDB:YPR002W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable 2 iron, 2 sulfur cluster binding activity and 2-methylcitrate dehydratase activity. Involved in propionate metabolic process. Located in mitochondrial outer membrane. Orthologous to human ACOD1 (aconitate decarboxylase 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See PDH1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (558385..559935)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene histone acetyltransferase catalytic subunit HAT1 Neighboring gene citrate (Si)-synthase CIT3 Neighboring gene tRNA-Phe Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The yeast mitochondrial proteome, a study of fermentative and respiratory growth. Ohlmeier S, et al. J Biol Chem, 2004 Feb 6. PMID 14597615
  2. Propionate catabolism in Salmonella typhimurium LT2: two divergently transcribed units comprise the prp locus at 8.5 centisomes, prpR encodes a member of the sigma-54 family of activators, and the prpBCDE genes constitute an operon. Horswill AR, et al. J Bacteriol, 1997 Feb. PMID 9006051, Free PMC Article
  3. Genome-wide responses to mitochondrial dysfunction. Epstein CB, et al. Mol Biol Cell, 2001 Feb. PMID 11179416, Free PMC Article
  4. Interactomic study on interaction between lipid droplets and mitochondria. Pu J, et al. Protein Cell, 2011 Jun. PMID 21748599, Free PMC Article
  5. Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins. Zahedi RP, et al. Mol Biol Cell, 2006 Mar. PMID 16407407, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 2-methylcitrate dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in propionate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in propionate metabolic process, methylcitrate cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in mitochondrial outer membrane HDA PubMed 
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
putative 2-methylcitrate dehydratase
NP_015326.1
  • Putative 2-methylcitrate dehydratase; mitochondrial protein that participates in respiration; induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    558385..559935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184099.1 → NP_015326.1  TPA: putative 2-methylcitrate dehydratase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015326.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W413, Q12428
    UniProtKB/TrEMBL
    A6ZWP7, B3LL63, B5VTG2, C7GV44, C8ZJ27, G2WPI1, N1NW72
    Conserved Domains (1) summary
    PRK09425
    Location:27 → 513
    prpD; bifunctional 2-methylcitrate dehydratase/aconitate hydratase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12428.1

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