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CIP1 Cip1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856093, updated on 4-Jan-2025

Summary

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Official Symbol
CIP1
Official Full Name
Cip1p
Primary source
SGD:S000005935
Locus tag
YPL014W
See related
AllianceGenome:SGD:S000005935; FungiDB:YPL014W; VEuPathDB:YPL014W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in G1/S transition of mitotic cell cycle and negative regulation of protein phosphorylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See CIP1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (527547..528692)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Swi1p Neighboring gene histone deacetylase HST2 Neighboring gene mitochondrial 37S ribosomal protein MRPS16 Neighboring gene mRNA-binding protein RRP12

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cip1 tunes cell cycle arrest duration upon calcineurin activation. Flynn MJ, et al. Proc Natl Acad Sci U S A, 2022 Jun 7. PMID 35653562, Free PMC Article
  2. Cdk1-interacting protein Cip1 is regulated by the S phase checkpoint in response to genotoxic stress. Zhang Z, et al. Genes Cells, 2017 Oct. PMID 28771906, Free PMC Article
  3. Identification of YPL014W (Cip1) as a novel negative regulator of cyclin-dependent kinase in Saccharomyces cerevisiae. Ren P, et al. Genes Cells, 2016 Jun. PMID 27005485
  4. Dual Repressive Function by Cip1, a Budding Yeast Analog of p21, in Cell-Cycle START Regulation. Li P, et al. Front Microbiol, 2020. PMID 32733430, Free PMC Article
  5. Yeast Cip1 is activated by environmental stress to inhibit Cdk1-G1 cyclins via Mcm1 and Msn2/4. Chang YL, et al. Nat Commun, 2017 Jul 4. PMID 28676626, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cip1 tunes cell cycle arrest duration upon calcineurin activation.
    Title: Cip1 tunes cell cycle arrest duration upon calcineurin activation.
  2. Cip1 accumulates dramatically in a Mec1- and Rad53-dependent manner upon replication stress. Cip1 is phosphorylated at an S/TQ consensus motif in a Mec1-dependent manner. Deletion of Cip1 affects proliferation in hydroxyurea-containing plates.
    Title: Cdk1-interacting protein Cip1 is regulated by the S phase checkpoint in response to genotoxic stress.
  3. functions similarly to mammalian p21 as a stress-induced CDK inhibitor to decelerate cell cycle through G1 cyclins to cope with environmental stresses; regulated by cycle (Mcm1) and stress-mediated (Msn 2/4) transcription factors
    Title: Yeast Cip1 is activated by environmental stress to inhibit Cdk1-G1 cyclins via Mcm1 and Msn2/4.
  4. Study reports a novel Cdk1-interacting protein, YPL014W, named Cip1 (for Cdk1-interacting protein 1); results show that Cip1 specifically interacts with G1 /S-phase Cln2-Cdk1 complex but not with S-phase Clb5-Cdk1 or M-phase Clb2-Cdk1 complexes.
    Title: Identification of YPL014W (Cip1) as a novel negative regulator of cyclin-dependent kinase in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cip1p
NP_015311.1
  • Cyclin-dependent kinase inhibitor; activated by environmental stress; interacts with and inhibits the Cdc28p/Cln2p, G1/S phase cyclin-dependent kinase complex but not S-phase, or M-phase complexes; overexpression blocks cells in G1 phase and stabilizes the Cdc28p inhibitor Sic1p, while disruption accelerates the G1/S phase transition; phosphorylated during S phase in a Cdc28p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    527547..528692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183828.1 → NP_015311.1  TPA: Cip1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015311.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3Z8, Q02606
    UniProtKB/TrEMBL
    A6ZWN2, B3LL48, C7GU36, C8ZJ14, N1NVI7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02606.1

Gene LinkOut

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