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aldo-keto reductase superfamily protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 856017, updated on 4-Jan-2025

Summary

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Official Full Name
aldo-keto reductase superfamily protein
Primary source
SGD:S000006009
Locus tag
YPL088W
See related
AllianceGenome:SGD:S000006009; FungiDB:YPL088W; VEuPathDB:YPL088W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable aryl-alcohol dehydrogenase (NADP+) activity. Predicted to be involved in aldehyde metabolic process. Located in cytosol. Human ortholog(s) of this gene implicated in temporal lobe epilepsy. Orthologous to several human genes including KCNAB1 (potassium voltage-gated channel subfamily A regulatory beta subunit 1) and KCNAB3 (potassium voltage-gated channel subfamily A regulatory beta subunit 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (381965..382993)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S6A Neighboring gene Rlm1p Neighboring gene alkaline dihydroceramidase Neighboring gene Elongator subunit ELP3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Predicting subcellular localization of proteins using protein-protein interaction data. Garapati HS, et al. Genomics, 2020 May. PMID 31945465
  2. Disruption of seven hypothetical aryl alcohol dehydrogenase genes from Saccharomyces cerevisiae and construction of a multiple knock-out strain. Delneri D, et al. Yeast, 1999 Nov. PMID 10572264
  3. Competitive promoter occupancy by two yeast paralogous transcription factors controlling the multidrug resistance phenomenon. Lucau-Danila A, et al. J Biol Chem, 2003 Dec 26. PMID 14512416
  4. Network Rewiring of Homologous Recombination Enzymes during Mitotic Proliferation and Meiosis. Wild P, et al. Mol Cell, 2019 Aug 22. PMID 31351878, Free PMC Article
  5. Annotating novel genes by integrating synthetic lethals and genomic information. Schöner D, et al. BMC Syst Biol, 2008 Jan 14. PMID 18194531, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables aryl-alcohol dehydrogenase (NADP+) activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aldehyde metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
aldo-keto reductase superfamily protein
NP_015237.1
  • Putative aryl alcohol dehydrogenase; localizes to cytosol; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    381965..382993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183902.1 → NP_015237.1  TPA: aldo-keto reductase superfamily protein [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015237.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3S9, Q02895
    UniProtKB/TrEMBL
    G2WP93, N1NVH2
    Conserved Domains (1) summary
    cd19079
    Location:5 → 332
    AKR_EcYajO-like; Escherichia coli YajO and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02895.1

Gene LinkOut

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