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FEX2 fluoride transporter [ Saccharomyces cerevisiae S288C ]

Gene ID: 855850, updated on 4-Jan-2025

Summary

Official Symbol
FEX2
Official Full Name
fluoride transporter
Primary source
SGD:S000006200
Locus tag
YPL279C
See related
AllianceGenome:SGD:S000006200; FungiDB:YPL279C; VEuPathDB:YPL279C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables fluoride transmembrane transporter activity. Involved in fluoride transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See FEX2 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (13228..14355, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene phosphopyruvate hydratase ERR2 Neighboring gene glutathione-independent methylglyoxalase family protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables fluoride transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fluoride transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables fluoride transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in fluoride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fluoride transmembrane transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in fluoride transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
fluoride transporter
NP_015044.1
  • Protein involved in fluoride export; nearly identical to FEX1, and deletion of both proteins results in a large increase in fluoride sensitivity compared with the single mutant; contains two FEX domains connected by a linker; part of a widespread family of conserved fluoride export proteins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    13228..14355 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184093.1NP_015044.1  TPA: fluoride transporter [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015044.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W393, Q08991
    UniProtKB/TrEMBL
    A6ZVX9
    Conserved Domains (2) summary
    COG0239
    Location:240370
    CrcB; Fluoride ion exporter CrcB/FEX, affects chromosome condensation [Cell cycle control, cell division, chromosome partitioning, Inorganic ion transport and metabolism]
    pfam02537
    Location:53104
    CRCB; CrcB-like protein, Camphor Resistance (CrcB)