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NRM1 Nrm1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855743, updated on 4-Jan-2025

Summary

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Official Symbol
NRM1
Official Full Name
Nrm1p
Primary source
SGD:S000005292
Locus tag
YNR009W
See related
AllianceGenome:SGD:S000005292; FungiDB:YNR009W; VEuPathDB:YNR009W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables DNA-binding transcription factor binding activity. Involved in G1/S transition of mitotic cell cycle and negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of MBF transcription complex. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See NRM1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (642690..643439)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Atg3p Neighboring gene phospholipid:diacylglycerol acyltransferase Neighboring gene Cse2p Neighboring gene DEAH-box RNA-dependent ATPase PRP2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DNA replication stress differentially regulates G1/S genes via Rad53-dependent inactivation of Nrm1. Travesa A, et al. EMBO J, 2012 Apr 4. PMID 22333915, Free PMC Article
  2. Mutations in the Non-Catalytic Subunit Dpb2 of DNA Polymerase Epsilon Affect the Nrm1 Branch of the DNA Replication Checkpoint. Dmowski M, et al. PLoS Genet, 2017 Jan. PMID 28107343, Free PMC Article
  3. Binding specificity of the G1/S transcriptional regulators in budding yeast. Harris MR, et al. PLoS One, 2013. PMID 23593391, Free PMC Article
  4. Repression of G1/S transcription is mediated via interaction of the GTB motifs of Nrm1 and Whi5 with Swi6. Travesa A, et al. Mol Cell Biol, 2013 Apr. PMID 23382076, Free PMC Article
  5. Role of a Candida albicans Nrm1/Whi5 homologue in cell cycle gene expression and DNA replication stress response. Ofir A, et al. Mol Microbiol, 2012 May. PMID 22463761, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study describes a protein motif, the GTB motif (for G1/S transcription factor binding), in Nrm1 and Whi5 that is required to bind to the transcription factors
    Title: Repression of G1/S transcription is mediated via interaction of the GTB motifs of Nrm1 and Whi5 with Swi6.
  2. It was shown that genotoxic stress during S phase specifically induces MBF-regulated genes via direct phosphorylation of Nrm1 by Rad53, the effector checkpoint kinase.
    Title: DNA replication stress differentially regulates G1/S genes via Rad53-dependent inactivation of Nrm1.
  3. APC(Cdh1) targeted Nrm1 and Yhp1 for degradation in early G1 phase
    Title: Anaphase promoting complex-dependent degradation of transcriptional repressors Nrm1 and Yhp1 in Saccharomyces cerevisiae.
  4. A negative feedback loop involving Nrm1 bound to MBF leads to transcriptional repression as cells exit G1 phase.
    Title: Constraining G1-specific transcription to late G1 phase: the MBF-associated corepressor Nrm1 acts via negative feedback.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of MBF transcription complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nrm1p
NP_014406.1
  • Transcriptional co-repressor of MBF-regulated gene expression; Nrm1p associates stably with promoters via MCB binding factor (MBF) to repress transcription upon exit from G1 phase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    642690..643439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183186.1 → NP_014406.1  TPA: Nrm1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014406.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZS83, D6W1I4, P53718
    UniProtKB/TrEMBL
    B3LPN1, B5VR40, C7GLP6, C8ZFN6, G2WL66, N1NXQ5
    Conserved Domains (1) summary
    pfam08528
    Location:103 → 127
    Whi5; Whi5 like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53718.1

Gene LinkOut

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