U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

IMP4 snoRNA-binding rRNA-processing protein IMP4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855649, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
IMP4
Official Full Name
snoRNA-binding rRNA-processing protein IMP4
Primary source
SGD:S000005019
Locus tag
YNL075W
See related
AllianceGenome:SGD:S000005019; FungiDB:YNL075W; VEuPathDB:YNL075W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables rRNA primary transcript binding activity; single-stranded telomeric DNA binding activity; and snoRNA binding activity. Involved in rRNA processing and ribosomal small subunit biogenesis. Part of Mpp10 complex and small-subunit processome. Orthologous to human IMP4 (IMP U3 small nucleolar ribonucleoprotein 4). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See IMP4 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (485607..486479)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Apj1p Neighboring gene Mks1p Neighboring gene Mlf3p Neighboring gene lysine--tRNA ligase MSK1

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The U3 small nucleolar ribonucleoprotein component Imp4p is a telomeric DNA-binding protein. Hsieh YC, et al. Biochem J, 2007 Dec 15. PMID 17803460, Free PMC Article
  2. Schistosoma mansoni: the IMP4 gene is involved in DNA repair/tolerance after treatment with alkylating agent methyl methane sulfonate. Furtado C, et al. Exp Parasitol, 2007 May. PMID 17189633
  3. RNA chaperones stimulate formation and yield of the U3 snoRNA-Pre-rRNA duplexes needed for eukaryotic ribosome biogenesis. Gérczei T, et al. J Mol Biol, 2009 Jul 31. PMID 19482034, Free PMC Article
  4. Two-hybrid Mpp10p interaction-defective Imp4 proteins are not interaction defective in vivo but do confer specific pre-rRNA processing defects in Saccharomyces cerevisiae. Gallagher JE, et al. Nucleic Acids Res, 2004. PMID 14990745, Free PMC Article
  5. Imp3p and Imp4p, two specific components of the U3 small nucleolar ribonucleoprotein that are essential for pre-18S rRNA processing. Lee SJ, et al. Mol Cell Biol, 1999 Aug. PMID 10409734, Free PMC Article

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Imp4p is a novel telomeric DNA-binding protein that, in addition to its role in rRNA processing, might participate in telomere function
    Title: The U3 small nucleolar ribonucleoprotein component Imp4p is a telomeric DNA-binding protein.
  2. Imp3p and Imp4p may help the small subunit processome to dock onto the pre-rRNA, an event indispensable for ribosome biogenesis and hence for cell growth
    Title: Imp3p and Imp4p mediate formation of essential U3-precursor rRNA (pre-rRNA) duplexes, possibly to recruit the small subunit processome to the pre-rRNA.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables rRNA primary transcript binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables rRNA primary transcript binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded telomeric DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables snoRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal small subunit biogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of 90S preribosome HDA PubMed 
part_of Mpp10 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Mpp10 complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
snoRNA-binding rRNA-processing protein IMP4
NP_014324.3
  • Component of the SSU processome; SSU processome is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    485607..486479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182913.3 → NP_014324.3  TPA: snoRNA-binding rRNA-processing protein IMP4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014324.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1A4, P53941
    UniProtKB/TrEMBL
    A6ZS05, B3LNT4, B5VQX0, C7GUM5, C8ZGF5, G2WM29
    Conserved Domains (1) summary
    COG2136
    Location:85 → 268
    IMP4; rRNA maturation protein Rpf1, contains Brix/IMP4 (anticodon-binding) domain [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53941.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous