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GLC8 Glc8p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855359, updated on 4-Jan-2025

Summary

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Official Symbol
GLC8
Official Full Name
Glc8p
Primary source
SGD:S000004928
Locus tag
YMR311C
See related
AllianceGenome:SGD:S000004928; FungiDB:YMR311C; VEuPathDB:YMR311C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables enzyme activator activity. Involved in chromosome segregation. Located in cytoplasm and nucleus. Orthologous to human PPP1R2 (protein phosphatase 1 regulatory inhibitor subunit 2) and PPP1R2P1 (protein phosphatase 1 regulatory inhibitor subunit 2 pseudogene 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See GLC8 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (896914..897603, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene translation initiation factor eIF3 core subunit c Neighboring gene putative methyltransferase Neighboring gene Elongator subunit ELP6 Neighboring gene bifunctional triglyceride lipase/lysophosphatidylethanolamine acyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inhibitor-1 interaction domain that mediates the inhibition of protein phosphatase-1. Connor JH, et al. J Biol Chem, 1998 Oct 16. PMID 9765309
  2. Regulation of chromosome segregation by Glc8p, a structural homolog of mammalian inhibitor 2 that functions as both an activator and an inhibitor of yeast protein phosphatase 1. Tung HY, et al. Mol Cell Biol, 1995 Nov. PMID 7565759, Free PMC Article
  3. Sli15 associates with the ipl1 protein kinase to promote proper chromosome segregation in Saccharomyces cerevisiae. Kim JH, et al. J Cell Biol, 1999 Jun 28. PMID 10385519, Free PMC Article
  4. Phosphorylation and functions of inhibitor-2 family of proteins. Li M, et al. Biochemistry, 2007 Mar 6. PMID 17286390
  5. Glc8 is a glucose-repressible activator of Glc7 protein phosphatase-1. Nigavekar SS, et al. Arch Biochem Biophys, 2002 Aug 1. PMID 12127071

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that the Cdc48(Shp1) complex controls Glc7 activity by regulating its interaction with Glc8 and possibly further regulatory subunits.
    Title: The budding yeast Cdc48(Shp1) complex promotes cell cycle progression by positive regulation of protein phosphatase 1 (Glc7).
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables enzyme activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycogen biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
Glc8p
NP_014042.1
  • Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    896914..897603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182822.1 → NP_014042.1  TPA: Glc8p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014042.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0D8, P41818
    UniProtKB/TrEMBL
    A6ZN28, B3LMJ9, B5VQ77, C7GPV2, C8ZFI2, G2WL20, N1NZ84
    Conserved Domains (1) summary
    pfam04979
    Location:91 → 201
    IPP-2; Protein phosphatase inhibitor 2 (IPP-2)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41818.1

Gene LinkOut

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