COA6 Coa6p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: COA6
Official Full Name: Coa6p
Primary source: SGD:S000004857
Locus tag: YMR244C-A
See related: AllianceGenome:SGD:S000004857; FungiDB:YMR244C-A; VEuPathDB:YMR244C-A
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables copper ion binding activity. Involved in intracellular copper ion homeostasis and mitochondrial cytochrome c oxidase assembly. Located in mitochondrial intermembrane space. Used to study COX deficiency, infantile mitochondrial myopathy; cardiomyopathy; and cytochrome-c oxidase deficiency disease. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 13. Orthologous to human COA6 (cytochrome c oxidase assembly factor 6). [provided by Alliance of Genome Resources, Jan 2025]
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Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

we found that simultaneous deletion of Coa6 and Sco2 completely abrogates Cox2 biogenesis.
Title: Mitochondrial disease genes COA6, COX6B and SCO2 have overlapping roles in COX2 biogenesis.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables copper ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular copper ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial cytochrome c oxidase assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial cytochrome c oxidase assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial intermembrane space	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_013972.1

Protein involved in cytochrome c oxidase (Complex IV) assembly; involved in delivery of copper to Complex IV; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; ortholog implicated in cardiac defects in zebrafish and human; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress