U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

FUS2 Fus2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855272, updated on 4-Jan-2025

Summary

Official Symbol
FUS2
Official Full Name
Fus2p
Primary source
SGD:S000004845
Locus tag
YMR232W
See related
AllianceGenome:SGD:S000004845; FungiDB:YMR232W; VEuPathDB:YMR232W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in cytogamy and karyogamy involved in conjugation with cellular fusion. Located in cytoplasm; mating projection tip; and nucleus. [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See FUS2 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (736926..738959)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tethering complex subunit PEP5 Neighboring gene Tri1p Neighboring gene RNA-DNA hybrid ribonuclease

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytogamy IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cytogamy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in karyogamy involved in conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of actomyosin contractile ring contraction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of division septum assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cell tip IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in mating projection tip IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Fus2p
NP_013959.1
  • Cell fusion regulator; cytoplasmic protein localized to shmoo tip; required for alignment of parental nuclei before nuclear fusion during mating; contains a Dbl-homology domain; binds specifically with activated Cdc42p

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    736926..738959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182739.1NP_013959.1  TPA: Fus2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013959.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W058, Q05023, Q05670
    UniProtKB/TrEMBL
    B3LMC1, C7GRB8, C8ZF97, N1P0K3
    Conserved Domains (1) summary
    cl02571
    Location:114301
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.