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CVM1 Cvm1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855195, updated on 4-Jan-2025

Summary

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Official Symbol
CVM1
Official Full Name
Cvm1p
Primary source
SGD:S000004770
Locus tag
YMR160W
See related
AllianceGenome:SGD:S000004770; FungiDB:YMR160W; VEuPathDB:YMR160W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in sphingolipid metabolic process. Located in fungal-type vacuole membrane. Is active in endoplasmic reticulum-vacuole membrane contact site; peroxisomal membrane; and vacuole-mitochondrion membrane contact site. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See CVM1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (575066..577516)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Atg16p Neighboring gene type I HSP40 co-chaperone HLJ1 Neighboring gene aminophospholipid-translocating P4-type ATPase DNF3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cvm1 is a component of multiple vacuolar contact sites required for sphingolipid homeostasis. Bisinski DD, et al. J Cell Biol, 2022 Aug 1. PMID 35766971, Free PMC Article
  2. Global analysis of Cdc14 phosphatase reveals diverse roles in mitotic processes. Bloom J, et al. J Biol Chem, 2011 Feb 18. PMID 21127052, Free PMC Article
  3. Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. Willingham S, et al. Science, 2003 Dec 5. PMID 14657499
  4. Yeast Saccharomyces cerevisiae adiponectin receptor homolog Izh2 is involved in the regulation of zinc, phospholipid and pH homeostasis. Mattiazzi Ušaj M, et al. Metallomics, 2015 Sep. PMID 26067383
  5. Elucidation of the interaction proteome of mitochondrial chaperone Hsp78 highlights its role in protein aggregation during heat stress. Jaworek W, et al. J Biol Chem, 2022 Oct. PMID 36115461, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cvm1 is a component of multiple vacuolar contact sites required for sphingolipid homeostasis.
    Title: Cvm1 is a component of multiple vacuolar contact sites required for sphingolipid homeostasis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in sphingolipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum-vacuole membrane contact site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in peroxisomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in vacuole-mitochondrion membrane contact site IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Cvm1p
NP_013883.1
  • Protein involved in sphingolipid metabolism; localizes to vacuolar contact sites with mitochondria, ER and peroxisomes; mutant has enhanced sensitivity to overexpression of mutant huntingtin; relative distribution within the vacuolar membrane changes upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    575066..577516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182664.1 → NP_013883.1  TPA: Cvm1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013883.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZY2, Q03823
    UniProtKB/TrEMBL
    A6ZML9, B5VPT0, C7GU62, N1NYH3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03823.1

Gene LinkOut

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