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IRC21 Irc21p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855095, updated on 4-Jan-2025

Summary

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Official Symbol
IRC21
Official Full Name
Irc21p
Primary source
SGD:S000004677
Locus tag
YMR073C
See related
AllianceGenome:SGD:S000004677; FungiDB:YMR073C; VEuPathDB:YMR073C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable cytochrome-b5 reductase activity, acting on NAD(P)H and heme binding activity. Involved in DNA damage response. Located in cytoplasm. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CYB5R4 (cytochrome b5 reductase 4). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See IRC21 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (412268..412873, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Tvp18p Neighboring gene DNA-binding protein ABF2 Neighboring gene Sdd2p Neighboring gene Rco1p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dissection of DNA damage responses using multiconditional genetic interaction maps. Guénolé A, et al. Mol Cell, 2013 Jan 24. PMID 23273983, Free PMC Article
  2. Genome-wide requirements for resistance to functionally distinct DNA-damaging agents. Lee W, et al. PLoS Genet, 2005 Aug. PMID 16121259, Free PMC Article
  3. Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination. Alvaro D, et al. PLoS Genet, 2007 Dec. PMID 18085829, Free PMC Article
  4. A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae. Gallego O, et al. Mol Syst Biol, 2010 Nov 30. PMID 21119626, Free PMC Article
  5. PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response. Ferrari E, et al. Mol Cell, 2017 Jul 20. PMID 28648781, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cytochrome-b5 reductase activity, acting on NAD(P)H IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to xenobiotic stimulus HMP PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Irc21p
NP_013789.1
  • hypothetical protein; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    412268..412873 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182571.1 → NP_013789.1  TPA: Irc21p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013789.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZP7, Q04772
    UniProtKB/TrEMBL
    B3LLW6, B5VPJ9, C7GL51, C8ZES5
    Conserved Domains (1) summary
    COG5274
    Location:30 → 199
    CYB5; Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04772.1

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