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PML39 Pml39p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854864, updated on 4-Jan-2025

Summary

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Official Symbol
PML39
Official Full Name
Pml39p
Primary source
SGD:S000004575
Locus tag
YML107C
See related
AllianceGenome:SGD:S000004575; FungiDB:YML107C; VEuPathDB:YML107C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable zinc ion binding activity. Involved in maintenance of RNA location. Located in nuclear membrane. Part of nuclear pore nuclear basket. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See PML39 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (55265..56269, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Zds2p Neighboring gene uncharacterized protein Neighboring gene orotate phosphoribosyltransferase URA5 Neighboring gene RNA-binding signal recognition particle subunit SEC65

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of the pre-mRNA leakage 39-kDa protein reveals a single domain of integrated zf-C3HC and Rsm1 modules. Hashimoto H, et al. Sci Rep, 2022 Oct 21. PMID 36271106, Free PMC Article
  2. An evolutionarily conserved bimodular domain anchors ZC3HC1 and its yeast homologue Pml39p to the nuclear basket. Gunkel P, et al. Mol Biol Cell, 2023 May 1. PMID 36857168, Free PMC Article
  3. Pml39, a novel protein of the nuclear periphery required for nuclear retention of improper messenger ribonucleoparticles. Palancade B, et al. Mol Biol Cell, 2005 Nov. PMID 16162818, Free PMC Article
  4. Nuclear pore components affect distinct stages of intron-containing gene expression. Bonnet A, et al. Nucleic Acids Res, 2015 Apr 30. PMID 25845599, Free PMC Article
  5. Synthetic lethality of cohesins with PARPs and replication fork mediators. McLellan JL, et al. PLoS Genet, 2012. PMID 22412391, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structure of the pre-mRNA leakage 39-kDa protein reveals a single domain of integrated zf-C3HC and Rsm1 modules.
    Title: Structure of the pre-mRNA leakage 39-kDa protein reveals a single domain of integrated zf-C3HC and Rsm1 modules.
  2. Together, these data indicate that Pml39 is an upstream effector of the Mlps, involved in the retention of improper mRNPs in the nucleus before their export.
    Title: Pml39, a novel protein of the nuclear periphery required for nuclear retention of improper messenger ribonucleoparticles.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in maintenance of RNA location IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore nuclear basket IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Pml39p
NP_013600.2
  • Protein required for nuclear retention of unspliced pre-mRNAs; required along with Mlp1p and Pml1p; anchored to the nuclear pore complex through an interaction between its bimodular nuclear basket-interaction domain (NuBaID) and Mlp1p and Mlp2p; localizes to the nuclear basket enables linkage between subpopulations of Mlp1p; associates with the subset of nuclear pores farthest from the nucleolus; homologous to human ZC3HC1, a NuBaID containing protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    55265..56269 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182469.1 → NP_013600.2  TPA: Pml39p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013600.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0H7, Q03760
    UniProtKB/TrEMBL
    B3LLF2, G2WJU9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03760.2

Gene LinkOut

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