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SQT1 Sqt1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854829, updated on 4-Jan-2025

Summary

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Official Symbol
SQT1
Official Full Name
Sqt1p
Primary source
SGD:S000001451
Locus tag
YIR012W
See related
AllianceGenome:SGD:S000001451; FungiDB:YIR012W; VEuPathDB:YIR012W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables unfolded protein binding activity. Involved in ribosomal large subunit assembly. Located in cytosol. Orthologous to human AAMP (angio associated migratory cell protein). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See SQT1 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (378486..379781)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene MIND complex subunit DSN1 Neighboring gene Sts1p Neighboring gene Gat4p Neighboring gene Vld1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SQT1, which encodes an essential WD domain protein of Saccharomyces cerevisiae, suppresses dominant-negative mutations of the ribosomal protein gene QSR1. Eisinger DP, et al. Mol Cell Biol, 1997 Sep. PMID 9271392, Free PMC Article
  2. Sqt1p is an eight-bladed WD40 protein. Frénois F, et al. Acta Crystallogr F Struct Biol Commun, 2016 Jan. PMID 26750486, Free PMC Article
  3. GRC5 and NMD3 function in translational control of gene expression and interact genetically. Karl T, et al. Curr Genet, 1999 Jan. PMID 9933353
  4. Mutational analysis of the ribosomal protein Rpl10 from yeast. Hofer A, et al. J Biol Chem, 2007 Nov 9. PMID 17761675
  5. Defining the order in which Nmd3p and Rpl10p load onto nascent 60S ribosomal subunits. West M, et al. Mol Cell Biol, 2005 May. PMID 15831484, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables unfolded protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in ribosomal large subunit assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Sqt1p
NP_012277.1
  • Specific assembly chaperone for ribosomal protein Rpl10p; co-translationally associates with nascent Rpl10p, preventing aggregation; involved in biogenesis of the ribosomal large subunit; contains multiple WD repeats; interacts genetically and physically with Qsr1p; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    378486..379781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179534.1 → NP_012277.1  TPA: Sqt1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012277.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVU2, P35184
    UniProtKB/TrEMBL
    C7GJG0, G2WGF8, N1P2A9
    Conserved Domains (2) summary
    COG2319
    Location:51 → 392
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:68 → 107
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35184.2

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