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PCL7 Pcl7p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854761, updated on 4-Jan-2025

Summary

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Official Symbol
PCL7
Official Full Name
Pcl7p
Primary source
SGD:S000001312
Locus tag
YIL050W
See related
AllianceGenome:SGD:S000001312; FungiDB:YIL050W; VEuPathDB:YIL050W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in regulation of glycogen biosynthetic process; regulation of glycogen catabolic process; and regulation of protein stability. Located in nucleus. Part of cyclin-dependent protein kinase holoenzyme complex. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See PCL7 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (258913..259770)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L34B Neighboring gene isoleucine biosynthesis protein MMF1 Neighboring gene putative polyprenol reductase Neighboring gene putative aminophospholipid-translocating P4-type ATPase NEO1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [Phosphorylation of YLR190w by PAP1 PHO85 kinase complex]. Shi XZ, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 2002 Mar. PMID 12006994
  2. Cloning and Expression of a Novel PHO85 Associated Protein PAP1 Gene of Saccharomyces cerevisiae. Wu JS, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 1998. PMID 12174291
  3. Regulation of the Pcl7-Pho85 cyclin-cdk complex by Pho81. Lee M, et al. Mol Microbiol, 2000 Oct. PMID 11069666
  4. Analysis of phosphorylation of YJL084c, a yeast protein. Shi XZ, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 2002 Jul. PMID 12098764
  5. Yeast Gcn4p stabilization is initiated by the dissociation of the nuclear Pho85p/Pcl5p complex. Bömeke K, et al. Mol Biol Cell, 2006 Jul. PMID 16611745, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of glycogen biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of glycogen catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex IEA
Inferred from Electronic Annotation
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Pcl7p
NP_012214.3
  • Pho85p cyclin of the Pho80p subfamily; forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated; PCL7 has a paralog, PCL6, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    258913..259770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179400.3 → NP_012214.3  TPA: Pcl7p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012214.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVN1, P40186
    UniProtKB/TrEMBL
    A6ZVL9, B3LTQ6, C8ZAJ6, G2WG95, N1P0L4
    Conserved Domains (1) summary
    pfam08613
    Location:108 → 264
    Cyclin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40186.3

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