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KGD1 alpha-ketoglutarate dehydrogenase KGD1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854681, updated on 4-Jan-2025

Summary

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Official Symbol
KGD1
Official Full Name
alpha-ketoglutarate dehydrogenase KGD1
Primary source
SGD:S000001387
Locus tag
YIL125W
See related
AllianceGenome:SGD:S000001387; FungiDB:YIL125W; VEuPathDB:YIL125W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
OGD1
Summary
Predicted to enable oxoglutarate dehydrogenase (succinyl-transferring) activity. Predicted to be involved in tricarboxylic acid cycle. Located in mitochondrial nucleoid. Part of oxoglutarate dehydrogenase complex. Human ortholog(s) of this gene implicated in Yoon-Bellen neurodevelopmental syndrome and oxoglutarate dehydrogenase deficiency. Orthologous to several human genes including OGDH (oxoglutarate dehydrogenase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See KGD1 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (122689..125733)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Rrt14p Neighboring gene RSC chromatin remodeling complex ATPase subunit STH1 Neighboring gene acylglycerone-phosphate reductase Neighboring gene putative glucosidase SIM1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The OGD1 gene, affecting 2-oxoglutarate dehydrogenase in S. cerevisiae, is closely linked to HIS5 on chromosome IX. Ruttkay-Nedecký B, et al. Curr Genet, 1990 Jan. PMID 2178788
  2. The properties of the multicopy suppressor of the ogd1 mutation in yeast. Gbelská Y, et al. J Basic Microbiol, 1995. PMID 7473064
  3. The ogd1 and kgd1 mutants lacking 2-oxoglutarate dehydrogenase activity in yeast are allelic and can be differentiated by the cloned amber suppressor. Mockovciaková D, et al. Curr Genet, 1993 Nov. PMID 8299151
  4. Elucidation of ethanol tolerance mechanisms in Saccharomyces cerevisiae by global metabolite profiling. Kim S, et al. Biotechnol J, 2016 Sep. PMID 27313052
  5. Alpha-Ketoglutarate dehydrogenase and lipoic acid synthase are important for the functioning of peroxisomes of Saccharomyces cerevisiae. Smaczyńska-de Rooij I, et al. Cell Mol Biol Lett, 2004. PMID 15213808

See all (101) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables oxoglutarate dehydrogenase (succinyl-transferring) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxoglutarate dehydrogenase (succinyl-transferring) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxoglutarate dehydrogenase (succinyl-transferring) activity TAS
Traceable Author Statement
more info
 PubMed 
enables thiamine pyrophosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 2-oxoglutarate metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in cellular respiration TAS
Traceable Author Statement
more info
 PubMed 
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial nucleoid IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion HDA PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of oxoglutarate dehydrogenase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of oxoglutarate dehydrogenase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
alpha-ketoglutarate dehydrogenase KGD1
NP_012141.1
  • Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex; catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    122689..125733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179473.1 → NP_012141.1  TPA: alpha-ketoglutarate dehydrogenase KGD1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012141.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVG2, P20967
    UniProtKB/TrEMBL
    A6ZVF1, B3LTX2, C7GWJ5, C8ZAY8
    Conserved Domains (1) summary
    TIGR00239
    Location:44 → 1011
    2oxo_dh_E1; 2-oxoglutarate dehydrogenase, E1 component
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20967.2

Gene LinkOut

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