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UBP7 ubiquitin-specific protease UBP7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854650, updated on 4-Jan-2025

Summary

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Official Symbol
UBP7
Official Full Name
ubiquitin-specific protease UBP7
Primary source
SGD:S000001418
Locus tag
YIL156W
See related
AllianceGenome:SGD:S000001418; FungiDB:YIL156W; VEuPathDB:YIL156W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables cysteine-type deubiquitinase activity. Involved in protein deubiquitination. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 6. Orthologous to human USP26 (ubiquitin specific peptidase 26) and USP29 (ubiquitin specific peptidase 29). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See UBP7 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (48091..51306)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Coa1p Neighboring gene mitofissin Neighboring gene glycerol-3-phosphate dehydrogenase Neighboring gene Imp21p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Quantitative Proteomics-Based Substrate Screening Revealed Cyclophilin Stabilization Regulated by Deubiquitinase Ubp7. Wang Y, et al. J Proteome Res, 2023 Jul 7. PMID 37341107
  2. Small toxic protein encoded on chromosome VII of Saccharomyces cerevisiae. Makanae K, et al. PLoS One, 2015. PMID 25781884, Free PMC Article
  3. Regulation of clathrin-mediated endocytosis by dynamic ubiquitination and deubiquitination. Weinberg JS, et al. Curr Biol, 2014 May 5. PMID 24746795, Free PMC Article
  4. Hse1, a component of the yeast Hrs-STAM ubiquitin-sorting complex, associates with ubiquitin peptidases and a ligase to control sorting efficiency into multivesicular bodies. Ren J, et al. Mol Biol Cell, 2007 Jan. PMID 17079730, Free PMC Article
  5. Analysis of an inactivated Lg-FLO1 gene present in bottom-fermenting yeast. Sato M, et al. J Biosci Bioeng, 2002. PMID 16233220

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Quantitative Proteomics-Based Substrate Screening Revealed Cyclophilin Stabilization Regulated by Deubiquitinase Ubp7.
    Title: Quantitative Proteomics-Based Substrate Screening Revealed Cyclophilin Stabilization Regulated by Deubiquitinase Ubp7.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IC
Inferred by Curator
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin-specific protease UBP7
NP_012110.1
  • Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; involved in cell cycle progression through S phase; UBP7 has a paralog, UBP11, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    48091..51306
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179504.1 → NP_012110.1  TPA: ubiquitin-specific protease UBP7 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012110.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVD1, P40453
    UniProtKB/TrEMBL
    G2WFZ6, N1P451
    Conserved Domains (2) summary
    smart00450
    Location:328 → 443
    RHOD; Rhodanese Homology Domain
    pfam00443
    Location:609 → 1066
    UCH; Ubiquitin carboxyl-terminal hydrolase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40453.1

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