RPA43 DNA-directed RNA polymerase I subunit RPA43 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RPA43
Official Full Name: DNA-directed RNA polymerase I subunit RPA43
Primary source: SGD:S000005867
Locus tag: YOR340C
See related: AllianceGenome:SGD:S000005867; FungiDB:YOR340C; VEuPathDB:YOR340C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to RNA polymerase I activity. Involved in nucleolar large rRNA transcription by RNA polymerase I. Part of RNA polymerase I complex. Orthologous to human POLR1F (RNA polymerase I subunit F). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See RPA43 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (959202..960182, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Initiation-competent RNA polymerase I A43 subunit is associated with Rrn3, which stabilize A43.
Title: Structure of the initiation-competent RNA polymerase I and its implication for transcription.
Spt6 physically associates with a Pol I subunit (Rpa43).
Title: Spt6 Is Essential for rRNA Synthesis by RNA Polymerase I.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to RNA polymerase I activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in DNA-templated transcription initiation	IEA Inferred from Electronic Annotation more info
involved_in nucleolar large rRNA transcription by RNA polymerase I	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase I	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription elongation by RNA polymerase I	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase I complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase I complex	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA-directed RNA polymerase I subunit RPA43

NP_014985.1

RNA polymerase I subunit A43

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

959202..960182 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183760.1 → NP_014985.1 TPA: DNA-directed RNA polymerase I subunit RPA43 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014985.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W335, P46669, Q99187

UniProtKB/TrEMBL

A6ZPH0, B3LJZ9, B5VSL7, C7GNS6, C8ZH92, G2WNK2, N1NW87

Conserved Domains (2) summary

cd04328
Location:32 → 129

RNAP_I_Rpa43_N; Rpa43, N-terminal ribonucleoprotein (RNP) domain. Rpa43 is a subunit of eukaryotic RNA polymerase (RNAP) I that is homologous to Rpb7 of eukaryotic RNAP II, Rpc25 of eukaryotic RNP III, and RpoE of archaeal RNAP. Rpa43 has two domains, an N-terminal RNP ...

pfam17875
Location:127 → 250

RPA43_OB; RPA43 OB domain in RNA Pol I