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RAS1 Ras family GTPase RAS1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854268, updated on 4-Jan-2025

Summary

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Official Symbol
RAS1
Official Full Name
Ras family GTPase RAS1
Primary source
SGD:S000005627
Locus tag
YOR101W
See related
AllianceGenome:SGD:S000005627; FungiDB:YOR101W; VEuPathDB:YOR101W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of adenylate cyclase activity; and protein localization to bud neck. Located in plasma membrane. Used to study Costello syndrome; colorectal cancer; and urinary bladder cancer. Human ortholog(s) of this gene implicated in Noonan syndrome 12 and colorectal cancer. Orthologous to human RRAS (RAS related) and RRAS2 (RAS related 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See RAS1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (515244..516173)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene alpha-1,2-mannosyltransferase KTR1 Neighboring gene carnitine:acyl carnitine antiporter Neighboring gene dolichyl-diphosphooligosaccharide-protein glycotransferase Neighboring gene Pin2p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast alpha-mating factor receptor and G-protein-linked adenylyl cyclase inhibition requires RAS2 and GPA2 activities. Papasavvas S, et al. Biochem Biophys Res Commun, 1992 May 15. PMID 1317171
  2. Basidiomycetous ras cDNA functionally replaces its homolog genes in yeast. Ishibashi O, et al. Curr Genet, 1994 Jan. PMID 8082162
  3. Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins. Powers S, et al. Cell, 1984 Mar. PMID 6365329
  4. Carbon source regulation of RAS1 expression in Saccharomyces cerevisiae and the phenotypes of ras2- cells. Breviario D, et al. Proc Natl Acad Sci U S A, 1986 Jun. PMID 3520568, Free PMC Article
  5. Fatty acylation is important but not essential for Saccharomyces cerevisiae RAS function. Deschenes RJ, et al. Mol Cell Biol, 1987 Jul. PMID 3302674, Free PMC Article

See all (121) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ras1 activity was restricted by the guanosine triphosphatase-activating protein Gap1, which was itself recruited to sites of Ras1-GTP and was essential to block untimely fusion attempts.
    Title: Inhibition of Ras activity coordinates cell fusion with cell-cell contact during yeast mating.
  2. these data suggest a role of Ras1 phosphorylation in modulating nutrient signaling and stress response.
    Title: Nitrogen Starvation-induced Phosphorylation of Ras1 Protein and Its Potential Role in Nutrient Signaling and Stress Response.
  3. RAS1 regulates spore formation via Ras/cyclic AMP/protein kinase A pathway.
    Title: Acetate regulation of spore formation is under the control of the Ras/cyclic AMP/protein kinase A pathway and carbon dioxide in Saccharomyces cerevisiae.
  4. Data demonstrate that Whi2p-dependent regulation of cAMP-PKA signalling plays a physiological role in the differentiation of yeast colonies by facilitating elaboration of distinct zones of cell death.
    Title: Whi2p links nutritional sensing to actin-dependent Ras-cAMP-PKA regulation and apoptosis in yeast.
  5. These results indicate that the Ras/cAMP/PKA/Rim15/Msn2/4 and the Tor/Sch9/Rim15/Gis1 pathways are major mediators of the calorie restriction-dependent stress resistance and life span extension.
    Title: Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9.
  6. Ras and Gpa2 have roles in mediating glucose signaling
    Title: Ras and Gpa2 mediate one branch of a redundant glucose signaling pathway in yeast.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of adenylate cyclase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein localization to bud neck IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in cytoplasm HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ras family GTPase RAS1
NP_014744.1
  • GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in regulation of cell proliferation; localized to the plasma membrane; activated by increased levels of glycolysis intermediate fructose-1,6-bisphosphate; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress; RAS1 has a paralog, RAS2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    515244..516173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183520.1 → NP_014744.1  TPA: Ras family GTPase RAS1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014744.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2G2, P01119
    UniProtKB/TrEMBL
    G2WMX8, N1NWK3
    Conserved Domains (1) summary
    smart00010
    Location:9 → 172
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P01119.2

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