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MSA1 Msa1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854232, updated on 4-Jan-2025

Summary

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Official Symbol
MSA1
Official Full Name
Msa1p
Primary source
SGD:S000005592
Locus tag
YOR066W
See related
AllianceGenome:SGD:S000005592; FungiDB:YOR066W; VEuPathDB:YOR066W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YOR29-17
Summary
Involved in G1/S transition of mitotic cell cycle; regulation of transcription by RNA polymerase II; and traversing start control point of mitotic cell cycle. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See MSA1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (449436..451325)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Yng1p Neighboring gene ubiquinol--cytochrome-c reductase catalytic subunit CYT1 Neighboring gene dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase Neighboring gene Vam10p Neighboring gene sorting nexin 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Saccharomyces cerevisiae MSA1 mRNA has a sequence for localization at the bud tip. Takeuchi-Andoh T, et al. Biosci Biotechnol Biochem, 2017 Sep. PMID 28693383
  2. Hog1 targets Whi5 and Msa1 transcription factors to downregulate cyclin expression upon stress. González-Novo A, et al. Mol Cell Biol, 2015 May. PMID 25733686, Free PMC Article
  3. The transcription factors Tec1 and Ste12 interact with coregulators Msa1 and Msa2 to activate adhesion and multicellular development. van der Felden J, et al. Mol Cell Biol, 2014 Jun. PMID 24732795, Free PMC Article
  4. The SBF- and MBF-associated protein Msa1 is required for proper timing of G1-specific transcription in Saccharomyces cerevisiae. Ashe M, et al. J Biol Chem, 2008 Mar 7. PMID 18160399
  5. Identification of MSA1, a cell cycle-regulated, dosage suppressor of drc1/sld2 and dpb11 mutants. Li JM, et al. Cell Cycle, 2008 Nov 1. PMID 18948746

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a regulatory mechanism for Msa1p through the localized control of MSA1 mRNA
    Title: Saccharomyces cerevisiae MSA1 mRNA has a sequence for localization at the bud tip.
  2. Hog1 interacts with and phosphorylates components of the core cell cycle transcriptional machinery such as Whi5 and the coregulator Msa1. Phosphorylation of these two transcriptional regulators by Hog1 is essential for inhibition of G1 cyclin expression.
    Title: Hog1 targets Whi5 and Msa1 transcription factors to downregulate cyclin expression upon stress.
  3. MSA1 is a high copy suppressor of a drc1-1 mutant.
    Title: Identification of MSA1, a cell cycle-regulated, dosage suppressor of drc1/sld2 and dpb11 mutants.
  4. Msa1 acts to advance the timing of G(1)-specific transcription and cell cycle initiation
    Title: The SBF- and MBF-associated protein Msa1 is required for proper timing of G1-specific transcription in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in G1/S transition of mitotic cell cycle IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in traversing start control point of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in traversing start control point of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Msa1p
NP_014709.1
  • Activator of G1-specific transcription factors MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; MSA1 has a paralog, MSA2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    449436..451325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183485.1 → NP_014709.1  TPA: Msa1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014709.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2C9, O00026, Q08471
    UniProtKB/TrEMBL
    G2WMU4, N1NVR7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08471.1

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