IZH2 PAQR-type receptor [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: IZH2
Official Full Name: PAQR-type receptor
Primary source: SGD:S000005362
Locus tag: YOL002C
See related: AllianceGenome:SGD:S000005362; FungiDB:YOL002C; VEuPathDB:YOL002C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PHO36
Summary: Predicted to enable signaling receptor activity. Involved in intracellular zinc ion homeostasis; negative regulation of transcription by RNA polymerase II; and response to toxic substance. Located in plasma membrane. Human ortholog(s) of this gene implicated in breast cancer; macular degeneration; metabolic dysfunction-associated steatotic liver disease; prostate adenocarcinoma; and type 2 diabetes mellitus. Orthologous to several human genes including ADIPOR1 (adiponectin receptor 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See IZH2 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (323411..324364, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Studied yeast Izh2 protein and zinc ion homeostasis and in the regulation of lipid and phosphate metabolism.
Title: Yeast Saccharomyces cerevisiae adiponectin receptor homolog Izh2 is involved in the regulation of zinc, phospholipid and pH homeostasis.
IZH2 and IZH3 gene dosage affects resistance to polyene antifungal drugs
Title: Phylogenetic and preliminary phenotypic analysis of yeast PAQR receptors: potential antifungal targets.
Double disruption of the EOS1 and IZH2 genes yielded a slow-growth phenotype, suggesting that the two proteins are involved in related cellular processes.
Title: Multicopy suppression of oxidant-sensitive eos1 mutation by IZH2 in Saccharomyces cerevisiae and the involvement of Eos1 in zinc homeostasis.
Izh2p produces sphingoid bases, bioactive lipids which probably function as the second messenger responsible for the repressive effect of Izh2p on iron-uptake gene FET3.
Title: Sphingolipids function as downstream effectors of a fungal PAQR.
Izh2p negatively regulates functionally divergent genes through a CCCTC promoter motif.
Title: Dissecting the regulation of yeast genes by the osmotin receptor.
Data show that overproduction of Izh2p prevents the iron-dependent induction of the Fet3p component of the high-affinity iron-uptake system and is deleterious for growth in iron-limited medium.
Title: Probing the mechanism of FET3 repression by Izh2p overexpression.
Data show that the protein encoded by ORE20/PHO36 (YOL002c) is an osmotin binding plasma membrane protein that is required for full sensitivity to osmotin.
Title: Osmotin is a homolog of mammalian adiponectin and controls apoptosis in yeast through a homolog of mammalian adiponectin receptor.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in intracellular zinc ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular zinc ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in response to toxic substance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in fungal-type vacuole	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: PAQR-type receptor

NP_014641.2

Plasma membrane receptor for plant antifungal osmotin; involved in zinc ion homeostasis, apoptosis; negatively regulates ZRT1 and other functionally divergent genes through CCCTC promoter motif (IzRE); modulates FET3 activity in iron-independent manner; affects gene expression by influencing balance of competition between Msn2p/Msn4p and Nrg1p/Nrg2p for binding to IzRE; transcription regulated by Zap1p, zinc, fatty acid levels; homolog of mammalian adiponectin receptor