SPT23 Spt23p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SPT23
Official Full Name: Spt23p
Primary source: SGD:S000001503
Locus tag: YKL020C
See related: AllianceGenome:SGD:S000001503; FungiDB:YKL020C; VEuPathDB:YKL020C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Involved in cellular response to cold and regulation of biosynthetic process. Located in endoplasmic reticulum membrane and nucleus. Orthologous to human ANKFY1 (ankyrin repeat and FYVE domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See SPT23 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (398832..402080, complement)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of spt23 in Saccharomyces cerevisiae thermal tolerance.
Title: Role of spt23 in Saccharomyces cerevisiae thermal tolerance.
The COP9 signalosome mediates the Spt23 regulated fatty acid desaturation and ergosterol biosynthesis.
Title: The COP9 signalosome mediates the Spt23 regulated fatty acid desaturation and ergosterol biosynthesis.
the spt23Delta mutant strain shows similar ERG1 expression to wild-type cells, while the mga2Delta/spt23Delta strain shows reduced ERG1 expression, comparable to the mga2Delta, suggesting that the role of regulation of ERG1 transcription is unique to Mga2p.
Title: A role for MGA2, but not SPT23, in activation of transcription of ERG1 in Saccharomyces cerevisiae.
WW domains 2 and 3 of Rsp5p play overlapping roles in binding to the WW domain-binding site site on Spt23p and Mga2p
Title: WW domains 2 and 3 of Rsp5p play overlapping roles in binding to the LPKY motif of Spt23p and Mga2p.
Rsp5p, Spt23p and Mga2p may participate in the control of the homeostasis of lipids and lipid particles.
Title: Rsp5p ubiquitin ligase and the transcriptional activators Spt23p and Mga2p are involved in co-regulation of biosynthesis of end products of the mevalonate pathway and triacylglycerol in yeast Saccharomyces cerevisiae.
a PXY motif located within the carboxyl terminus of Spt23p and Mga2p mediates a physical and functional interaction with ubiquitin ligase Rsp5p
Title: A single PXY motif located within the carboxyl terminus of Spt23p and Mga2p mediates a physical and functional interaction with ubiquitin ligase Rsp5p.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cellular response to cold	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of unsaturated fatty acid biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in silent mating-type cassette heterochromatin formation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Spt23p

NP_012905.1

ER membrane protein involved in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting; SPT23 has a paralog, MGA2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

398832..402080 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179586.1 → NP_012905.1 TPA: Spt23p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012905.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXR5, P35210

UniProtKB/TrEMBL

G2WI10, N1P7Y4

Conserved Domains (5) summary

PLN03192
Location:612 → 765

PLN03192; Voltage-dependent potassium channel; Provisional

COG0666
Location:79 → 209

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00102
Location:508 → 578

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

sd00045
Location:709 → 740

ANK; ANK repeat [structural motif]

pfam12796
Location:694 → 772

Ank_2; Ankyrin repeats (3 copies)