TCD2 tRNA threonylcarbamoyladenosine dehydratase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: TCD2
Official Full Name: tRNA threonylcarbamoyladenosine dehydratase
Primary source: SGD:S000001510
Locus tag: YKL027W
See related: AllianceGenome:SGD:S000001510; FungiDB:YKL027W; VEuPathDB:YKL027W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables tRNA threonylcarbamoyladenosine dehydratase. Involved in cyclic threonylcarbamoyladenosine biosynthetic process. Located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Jan 2025]
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Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables tRNA threonylcarbamoyladenosine dehydratase	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA threonylcarbamoyladenosine dehydratase	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin-like modifier activating enzyme activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cyclic threonylcarbamoyladenosine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cyclic threonylcarbamoyladenosine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial outer membrane	HDA more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_012898.1

tRNA threonylcarbamoyladenosine dehydratase; required for the ct6A tRNA base modification, where an adenosine at position 37 is modified to form a cyclized active ester with an oxazolone ring; localized to the mitochondrial outer membrane; TCD2 has a paralog, TCD1, that arose from the whole genome duplication

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The following sections contain reference sequences that belong to a specific genome build. Explain