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L-methionine (R)-S-oxide reductase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853794, updated on 4-Jan-2025

Summary

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Official Full Name
L-methionine (R)-S-oxide reductase
Primary source
SGD:S000001552
Locus tag
YKL069W
See related
AllianceGenome:SGD:S000001552; FungiDB:YKL069W; VEuPathDB:YKL069W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YKG9
Summary
Enables L-methionine-(R)-S-oxide reductase activity. Involved in cellular response to oxidative stress. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (307285..307827)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Osi1p Neighboring gene uncharacterized protein Neighboring gene tRNA-Val Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cysteine-125 is the catalytic residue of Saccharomyces cerevisiae free methionine-R-sulfoxide reductase. Kwak GH, et al. Biochem Biophys Res Commun, 2010 May 7. PMID 20382110
  2. Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiae. Le DT, et al. J Biol Chem, 2009 Feb 13. PMID 19049972, Free PMC Article
  3. Compartmentalization and regulation of mitochondrial function by methionine sulfoxide reductases in yeast. Kaya A, et al. Biochemistry, 2010 Oct 5. PMID 20799725, Free PMC Article
  4. Dimethyl sulfoxide elevates hydrogen peroxide-mediated cell death in Saccharomyces cerevisiae by inhibiting the antioxidant function of methionine sulfoxide reductase A. Kwak GH, et al. BMB Rep, 2010 Sep. PMID 20846495
  5. Trapping redox partnerships in oxidant-sensitive proteins with a small, thiol-reactive cross-linker. Allan KM, et al. Free Radic Biol Med, 2016 Dec. PMID 27816612, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables L-methionine-(R)-S-oxide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-methionine-(R)-S-oxide reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-methionine-(R)-S-oxide reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
L-methionine (R)-S-oxide reductase
NP_012854.1
  • Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; capable of binding and degrading patulin, a polyketide mycotoxin, forming E-ascladiol; relative distribution to the nucleus increases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    307285..307827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179635.1 → NP_012854.1  TPA: L-methionine (R)-S-oxide reductase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012854.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXL7, P36088
    UniProtKB/TrEMBL
    A6ZZP6, B3LR21, B5VM88, C7GVN7, C8ZCA3, G2WHW2, N1NZ68
    Conserved Domains (1) summary
    COG1956
    Location:8 → 180
    GAF; GAF domain-containing protein, putative methionine-R-sulfoxide reductase [Defense mechanisms, Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36088.1

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