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VPH2 Vph2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853741, updated on 4-Jan-2025

Summary

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Official Symbol
VPH2
Official Full Name
Vph2p
Primary source
SGD:S000001602
Locus tag
YKL119C
See related
AllianceGenome:SGD:S000001602; FungiDB:YKL119C; VEuPathDB:YKL119C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CLS10; VMA12
Summary
Involved in vacuolar acidification and vacuolar proton-transporting V-type ATPase complex assembly. Located in endoplasmic reticulum membrane. Part of Vma12-Vma22 assembly complex. Used to study congenital disorder of glycosylation type IIp. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See VPH2 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (218570..219217, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Dgr2p Neighboring gene Oac1p Neighboring gene tRNA-Ala Neighboring gene Hsp90 cochaperone SBA1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The VPH2 gene encodes a 25 kDa protein required for activity of the yeast vacuolar H(+)-ATPase. Bachhawat AK, et al. Yeast, 1993 Feb. PMID 8465604
  2. Sequence of a segment of yeast chromosome XI identifies a new mitochondrial carrier, a new member of the G protein family, and a protein with the PAAKK motif of the H1 histones. Colleaux L, et al. Yeast, 1992 Apr. PMID 1514329
  3. Genes required for vacuolar acidity in Saccharomyces cerevisiae. Preston RA, et al. Genetics, 1992 Jul. PMID 1628805, Free PMC Article
  4. Vma22p is a novel endoplasmic reticulum-associated protein required for assembly of the yeast vacuolar H(+)-ATPase complex. Hill KJ, et al. J Biol Chem, 1995 Sep 22. PMID 7673216
  5. VMA12 is essential for assembly of the vacuolar H(+)-ATPase subunits onto the vacuolar membrane in Saccharomyces cerevisiae. Hirata R, et al. J Biol Chem, 1993 Jan 15. PMID 8419376

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in vacuolar acidification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vacuolar proton-transporting V-type ATPase complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in vacuolar proton-transporting V-type ATPase complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Vma12-Vma22 assembly complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Vph2p
NP_012803.1
  • Integral membrane protein required for V-ATPase function; not an actual component of the vacuolar H+-ATPase (V-ATPase) complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER); involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    218570..219217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179685.1 → NP_012803.1  TPA: Vph2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012803.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXH1, P32341
    UniProtKB/TrEMBL
    A6ZZK0, G2WHR7, N1P0S1
    Conserved Domains (1) summary
    pfam11712
    Location:64 → 196
    Vma12; Endoplasmic reticulum-based factor for assembly of V-ATPase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32341.1

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