GPM1 phosphoglycerate mutase GPM1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GPM1
Official Full Name: phosphoglycerate mutase GPM1
Primary source: SGD:S000001635
Locus tag: YKL152C
See related: AllianceGenome:SGD:S000001635; FungiDB:YKL152C; VEuPathDB:YKL152C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables phosphoglycerate mutase activity. Involved in gluconeogenesis and glycolytic process. Located in cytosol and mitochondrial intermembrane space. Human ortholog(s) of this gene implicated in familial erythrocytosis 8 and myoglobinuria. Orthologous to several human genes including PGAM1 (phosphoglycerate mutase 1) and PGAM2 (phosphoglycerate mutase 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See GPM1 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (163642..164385, complement)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

at this locus, the intergenic region serves as a focal point of regulatory input, driving antisense expression and mediating the coordinated regulation of YKL151C and GPM1 Together, our findings implicate transcription factors in the joint control of neighboring genes specialized to opposing conditions and the antisense transcripts expressed between them.
Title: The Role of Transcription Factors at Antisense-Expressing Gene Pairs in Yeast.
Findings strongly suggest a severely impaired growth ability of the GPM1 knock-out mutant, which presents increased transcript levels of genes involved in the pentose phosphate pathway and in the glyoxylate shunt.
Title: Phosphoglycerate mutase knock-out mutant Saccharomyces cerevisiae: physiological investigation and transcriptome analysis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity	IEA Inferred from Electronic Annotation more info
enables intramolecular phosphotransferase activity	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables phosphoglycerate mutase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoglycerate mutase activity	IEA Inferred from Electronic Annotation more info
enables phosphoglycerate mutase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphoglycerate mutase GPM1

NP_012770.1

EC 5.4.2.11

Tetrameric phosphoglycerate mutase; mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

163642..164385 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179718.1 → NP_012770.1 TPA: phosphoglycerate mutase GPM1 [Saccharomyces cerevisiae S288C]

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VX45, P00950, Q02117

UniProtKB/TrEMBL

A6ZZH0, B3LQU9, B5VM12, C7GU53, C8ZC23, G2WHN7, N1P8B2

Conserved Domains (1) summary

TIGR01258
Location:2 → 246

pgm_1; phosphoglycerate mutase, BPG-dependent, family 1