EBP2 Ebp2p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: EBP2
Official Full Name: Ebp2p
Primary source: SGD:S000001655
Locus tag: YKL172W
See related: AllianceGenome:SGD:S000001655; FungiDB:YKL172W; VEuPathDB:YKL172W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables mRNA binding activity. Involved in nuclear division and rRNA processing. Located in nuclear periphery and nucleolus. Part of preribosome, large subunit precursor. Orthologous to human EBNA1BP2 (EBNA1 binding protein 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See EBP2 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (125759..127042)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that Smy2 and Syh1 may be involved in ribosome biogenesis in relation to Ebp2.
Title: SMY2 and SYH1 suppress defects in ribosome biogenesis caused by ebp2 mutations.
Depletion of either Ebp2 or Brx1 revealed that Brx1 requires Ebp2 for its stable association with pre-ribosomes, but Ebp2 does not depend on the presence of Brx1 to enter pre-ribosomes.
Title: Ebp2 and Brx1 function cooperatively in 60S ribosomal subunit assembly in Saccharomyces cerevisiae.
These results suggest that the ribosome biogenesis factors Ebp2 and Rrs1 cooperate with Mps3 to mediate telomere clustering, but not telomere tethering, by binding Sir4.
Title: Ribosome biogenesis factors bind a nuclear envelope SUN domain protein to cluster yeast telomeres.
SUMO mediates the interaction between Ebp2p and SUMO related proteins and Ebp2p switches its interaction partners via sumoylation.
Title: SUMO mediates interaction of Ebp2p, the yeast homolog of Epstein-Barr virus nuclear antigen 1-binding protein 2, with a RING finger protein Ris1p.
Ebp2p is implicated in the secretory response, including changes in nucleolar architecture
Title: A ribosome assembly factor Ebp2p, the yeast homolog of EBNA1-binding protein 2, is involved in the secretory response.
plays a role in nuclear division in yeast and this function is separable from the role it plays in rRNA biosynthesis.
Title: The yeast rRNA biosynthesis factor Ebp2p is also required for efficient nuclear division.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables mRNA binding	HDA more info	PubMed

Process	Evidence Code	Pubs
involved_in nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal large subunit biogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nuclear periphery	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of preribosome, large subunit precursor	HDA more info	PubMed
part_of preribosome, large subunit precursor	IBA Inferred from Biological aspect of Ancestor more info
part_of preribosome, large subunit precursor	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Ebp2p

NP_012749.1

Protein required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

125759..127042

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179738.1 → NP_012749.1 TPA: Ebp2p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012749.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VX28, P36049

UniProtKB/TrEMBL

B3LQT3, N1P0N4

Conserved Domains (1) summary

pfam05890
Location:173 → 422

Ebp2; Eukaryotic rRNA processing protein EBP2