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TDA4 Tda4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853580, updated on 4-Jan-2025

Summary

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Official Symbol
TDA4
Official Full Name
Tda4p
Primary source
SGD:S000003877
Locus tag
YJR116W
See related
AllianceGenome:SGD:S000003877; FungiDB:YJR116W; VEuPathDB:YJR116W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to be involved in lipid homeostasis. Located in endoplasmic reticulum. Orthologous to human TLCD4 (TLC domain containing 4). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See TDA4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (640825..641664)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein RSM7 Neighboring gene uncharacterized protein Neighboring gene zinc metalloprotease Neighboring gene Ilm1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functions of Ceramide Synthase Paralogs YPR114w and YJR116w of Saccharomyces cerevisiae. Mallela SK, et al. PLoS One, 2016. PMID 26752183, Free PMC Article
  2. Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage. Reid RJ, et al. Genome Res, 2011 Mar. PMID 21173034, Free PMC Article
  3. Srs2 overexpression reveals a helicase-independent role at replication forks that requires diverse cell functions. León Ortiz AM, et al. DNA Repair (Amst), 2011 May 5. PMID 21459050, Free PMC Article
  4. Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X. Galibert F, et al. EMBO J, 1996 May 1. PMID 8641269, Free PMC Article
  5. A genome-wide enhancer screen implicates sphingolipid composition in vacuolar ATPase function in Saccharomyces cerevisiae. Finnigan GC, et al. Genetics, 2011 Mar. PMID 21196517, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Both yjr116w and ypr114w deleted mutants have fragmented vacuoles and produce less reactive oxygen species than wild type.
    Title: Functions of Ceramide Synthase Paralogs YPR114w and YJR116w of Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tda4p
NP_012650.1
  • Protein distantly similar to ceramide synthases, Lag1p and Lac1p; null mutant is sensitive to expression of the top1-T722A allele; mutation confers sensitivity to copper

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    640825..641664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181774.1 → NP_012650.1  TPA: Tda4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012650.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWT5, P47153
    UniProtKB/TrEMBL
    A6ZQ72, B3LQK0, C7GM95, C8ZBR4, G2WHB9, N1P1R4
    Conserved Domains (1) summary
    smart00724
    Location:72 → 271
    TLC; TRAM, LAG1 and CLN8 homology domains
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47153.1

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