U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SNX4 Snx4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853416, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
SNX4
Official Full Name
Snx4p
Primary source
SGD:S000003573
Locus tag
YJL036W
See related
AllianceGenome:SGD:S000003573; FungiDB:YJL036W; VEuPathDB:YJL036W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ATG24; CVT13
Summary
Enables phosphatidylinositol-3-phosphate binding activity. Involved in several processes, including endosomal transport; piecemeal microautophagy of the nucleus; and protein localization to organelle. Acts upstream of or within glycophagy. Located in several cellular components, including early endosome; perinuclear region of cytoplasm; and phagophore assembly site. Orthologous to human SNX7 (sorting nexin 7) and SNX30 (sorting nexin family member 30). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See SNX4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (378825..380096)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Irc18p Neighboring gene tRNA-Val Neighboring gene tRNA(adenine34) deaminase Neighboring gene Hsp70 family ATPase KAR2

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. SORTING NEXIN 1 Functions in Plant Salt Stress Tolerance Through Changes of NO Accumulation by Regulating NO Synthase-Like Activity. Li TT, et al. Front Plant Sci, 2018. PMID 30542353, Free PMC Article
  2. P4-ATPase endosomal recycling relies on multiple retromer-dependent localization signals. Jiménez M, et al. Mol Biol Cell, 2024 Oct 1. PMID 39110530, Free PMC Article
  3. Structure and function of yeast Atg20, a sorting nexin that facilitates autophagy induction. Popelka H, et al. Proc Natl Acad Sci U S A, 2017 Nov 21. PMID 29114050, Free PMC Article
  4. Cooperative binding of the cytoplasm to vacuole targeting pathway proteins, Cvt13 and Cvt20, to phosphatidylinositol 3-phosphate at the pre-autophagosomal structure is required for selective autophagy. Nice DC, et al. J Biol Chem, 2002 Aug 16. PMID 12048214, Free PMC Article
  5. Atg45 is an autophagy receptor for glycogen, a non-preferred cargo of bulk autophagy in yeast. Isoda T, et al. iScience, 2024 Jun 21. PMID 38832010, Free PMC Article

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3-phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagy of mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in early endosome to Golgi transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in early endosome to Golgi transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in early endosome to Golgi transport IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytic recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glycophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in piecemeal microautophagy of the nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to endosome IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein targeting to vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in reticulophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagophore assembly site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagophore assembly site membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Snx4p
NP_012498.1
  • Sorting nexin; involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    378825..380096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181470.1 → NP_012498.1  TPA: Snx4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012498.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWE7, P47057, Q06794
    UniProtKB/TrEMBL
    A6ZPU0, B3LQ75, C7GSQ8, C8ZBH7, G2WGY2, N1P1C9
    Conserved Domains (1) summary
    COG5391
    Location:1 → 423
    COG5391; Phox homology (PX) domain protein [Intracellular trafficking and secretion / General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47057.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools