ALY2 Aly2p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ALY2
Official Full Name: Aly2p
Primary source: SGD:S000003620
Locus tag: YJL084C
See related: AllianceGenome:SGD:S000003620; FungiDB:YJL084C; VEuPathDB:YJL084C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ART3
Summary: Enables protein-macromolecule adaptor activity and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to L-arginine; positive regulation of ubiquitin-dependent endocytosis; and ubiquitin-dependent endocytosis. Acts upstream of or within regulation of intracellular pH. Located in early endosome and late endosome. Orthologous to several human genes including ARRDC1 (arrestin domain containing 1); ARRDC2 (arrestin domain containing 2); and ARRDC3 (arrestin domain containing 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ALY2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (274862..278002, complement)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results indicate that the regulation of Dip5 endocytosis is accomplished by dynamic recruitment of Rsp5 via Aly2.
Title: Endocytosis of the aspartic acid/glutamic acid transporter Dip5 is triggered by substrate-dependent recruitment of the Rsp5 ubiquitin ligase via the arrestin-like protein Aly2.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ha2747 (e-PCR)
- UniSTS:515592

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-macromolecule adaptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to L-arginine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ubiquitin-dependent endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of intracellular pH	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of intracellular transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent endocytosis	ISA Inferred from Sequence Alignment more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Aly2p

NP_012451.1

Alpha arrestin, Ub-ligase adaptor for Rsp5p; controls nutrient limitation-mediated endosomal recycling of the Gap1p amino acid permease; PY motif-containing adaptor involved in substrate-induced, Rsp5p-mediated ubiquitination and endocytosis of select plasma membrane localized amino acid transporters, such as Dip5p and Put4p; regulates intracellular pH; phosphorylated by Npr1p and by the Pcl7p-Pho85p cyclin-CDK complex; interacts with AP-1 subunit Apl4p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

274862..278002 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181517.1 → NP_012451.1 TPA: Aly2p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012451.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VW99, P47029, Q05742

UniProtKB/TrEMBL

A6ZPP0, C7GR29, N1P331

Conserved Domains (3) summary

smart01017
Location:360 → 526

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

PTZ00112
Location:620 → 924

PTZ00112; origin recognition complex 1 protein; Provisional

cl22903
Location:254 → 341

Arrestin_N; Arrestin (or S-antigen), N-terminal domain