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RCY1 Rcy1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853226, updated on 4-Jan-2025

Summary

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Official Symbol
RCY1
Official Full Name
Rcy1p
Primary source
SGD:S000003740
Locus tag
YJL204C
See related
AllianceGenome:SGD:S000003740; FungiDB:YJL204C; VEuPathDB:YJL204C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables SNARE binding activity. Involved in early endosome to Golgi transport; endocytic recycling; and endocytosis. Located in Golgi apparatus; endosome; and site of polarized growth. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See RCY1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (50629..53151, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Nce101p Neighboring gene Prp21p Neighboring gene Ecm25p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The F-box protein Rcy1p is involved in endocytic membrane traffic and recycling out of an early endosome in Saccharomyces cerevisiae. Wiederkehr A, et al. J Cell Biol, 2000 Apr 17. PMID 10769031, Free PMC Article
  2. Interaction of the phospholipid flippase Drs2p with the F-box protein Rcy1p plays an important role in early endosome to trans-Golgi network vesicle transport in yeast. Hanamatsu H, et al. J Biochem, 2014 Jan. PMID 24272750
  3. Localization and functional requirement of yeast Na+/H+ exchanger, Nhx1p, in the endocytic and protein recycling pathway. Kojima A, et al. Biochim Biophys Acta, 2012 Feb. PMID 22210050
  4. P4-ATPase endosomal recycling relies on multiple retromer-dependent localization signals. Jiménez M, et al. Mol Biol Cell, 2024 Oct 1. PMID 39110530, Free PMC Article
  5. Endocytic uptake of fluorescence labelled DNA in yeast. Riechers SP, et al. J Basic Microbiol, 2010 Feb. PMID 20175124

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results reveal the involvement of Rcy1 in chromosome regulation and another regulatory pathway controlling the Cse4 level and activity.
    Title: The F-box Protein Rcy1 Is Involved in the Degradation of Histone H3 Variant Cse4 and Genome Maintenance.
  2. Ypt31/32 GTPases regulate the function of Rcy1 in the phosphorylation and/or ubiquitination of proteins that recycle through the Golgi
    Title: Ypt31/32 GTPases and their novel F-box effector protein Rcy1 regulate protein recycling.
  3. Ypt31p/32p-Rcy1p pathway regulates putative phospholipid translocases to promote formation of vesicles destined for the trans-Golgi network from early endosomes.
    Title: Endocytic recycling in yeast is regulated by putative phospholipid translocases and the Ypt31p/32p-Rcy1p pathway.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables SNARE binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in early endosome to Golgi transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytic recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell tip IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud HDA PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of exocyst IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in site of polarized growth IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Rcy1p
NP_012331.1
  • F-box protein involved in recycling endocytosed proteins; involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth; direct interaction with C-terminal cytoplasmic region of Drs2p plays an important role for Drs2p function in endocytic recycling pathway; required for turnover of histone H3 variant Cse4p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    50629..53151 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181637.1 → NP_012331.1  TPA: Rcy1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012331.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVZ0, P39530, P39531, P87193
    UniProtKB/TrEMBL
    N1P376
    Conserved Domains (1) summary
    pfam07393
    Location:101 → 827
    Sec10; Exocyst complex component Sec10
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39531.4

Gene LinkOut

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