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HXT8 hexose transporter HXT8 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853216, updated on 4-Jan-2025

Summary

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Official Symbol
HXT8
Official Full Name
hexose transporter HXT8
Primary source
SGD:S000003750
Locus tag
YJL214W
See related
AllianceGenome:SGD:S000003750; FungiDB:YJL214W; VEuPathDB:YJL214W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables D-glucose transmembrane transporter activity; fructose transmembrane transporter activity; and mannose transmembrane transporter activity. Involved in hexose transmembrane transport. Located in cell periphery. Orthologous to human SLC2A6 (solute carrier family 2 member 6) and SLC2A8 (solute carrier family 2 member 8). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See HXT8 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (26887..28596)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Ree1p Neighboring gene oligo-1,6-glucosidase IMA5 Neighboring gene uncharacterized protein Neighboring gene oligopeptide transporter OPT1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Uptake of radiolabeled GlcNAc into Saccharomyces cerevisiae via native hexose transporters and its in vivo incorporation into GPI precursors in cells expressing heterologous GlcNAc kinase. Scarcelli JJ, et al. FEMS Yeast Res, 2012 May. PMID 22151002, Free PMC Article
  2. Concurrent knock-out of at least 20 transporter genes is required to block uptake of hexoses in Saccharomyces cerevisiae. Wieczorke R, et al. FEBS Lett, 1999 Dec 31. PMID 10618490
  3. Selection of yeast Saccharomyces cerevisiae promoters available for xylose cultivation and fermentation. Nambu-Nishida Y, et al. J Biosci Bioeng, 2018 Jan. PMID 28869192
  4. Transcriptomic profiling of the Saccharomyces cerevisiae response to quinine reveals a glucose limitation response attributable to drug-induced inhibition of glucose uptake. dos Santos SC, et al. Antimicrob Agents Chemother, 2009 Dec. PMID 19805573, Free PMC Article
  5. Phospholipid transfer protein Sec14 is required for trafficking from endosomes and regulates distinct trans-Golgi export pathways. Curwin AJ, et al. J Biol Chem, 2009 Mar 13. PMID 19129178, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables D-glucose transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables carbohydrate:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fructose transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables mannose transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in hexose transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mannose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
hexose transporter HXT8
NP_012321.1
  • hypothetical protein with similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    26887..28596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181647.1 → NP_012321.1  TPA: hexose transporter HXT8 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012321.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVY1, P40886
    UniProtKB/TrEMBL
    G2WD81, N1P0E9
    Conserved Domains (1) summary
    pfam00083
    Location:69 → 530
    Sugar_tr; Sugar (and other) transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40886.1

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