RPS0A ribosomal 40S subunit protein S0A [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RPS0A
Official Full Name: ribosomal 40S subunit protein S0A
Primary source: SGD:S000003446
Locus tag: YGR214W
See related: AllianceGenome:SGD:S000003446; FungiDB:YGR214W; VEuPathDB:YGR214W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: NAB1; NAB1A; YST1
Summary: A structural constituent of ribosome. Involved in cytoplasmic translation and ribosome biogenesis. Located in cytoplasmic stress granule. Part of cytosolic small ribosomal subunit. Orthologous to human RPSA (ribosomal protein SA). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See RPS0A in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 2

Sequence:: Chromosome: VII; NC_001139.9 (920575..921788)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The interaction between the flexible RPS0A-C-terminal tail and residues 200-400 of the TIF32-N-terminal domain significantly stimulates attachment of eIF3 and its associated eIFs to small ribosomal subunits in vivo.
Title: Small ribosomal protein RPS0 stimulates translation initiation by mediating 40S-binding of eIF3 via its direct contact with the eIF3a/TIF32 subunit.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of ribosome	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoplasmic translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in ribosomal small subunit assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal small subunit assembly	IEA Inferred from Electronic Annotation more info
involved_in ribosomal small subunit assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal subunit export from nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of 90S preribosome	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	HDA more info	PubMed
part_of cytosolic small ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic small ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic small ribosomal subunit	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	IEA Inferred from Electronic Annotation more info
part_of small ribosomal subunit	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribosomal 40S subunit protein S0A

NP_011730.1

Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

920575..921788

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181343.1 → NP_011730.1 TPA: ribosomal 40S subunit protein S0A [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011730.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A6ZUM5, B3LI22, D6VUZ7, P32905

UniProtKB/TrEMBL

C8Z9A6, G2WEU3, N1P3Z7

Conserved Domains (1) summary

PTZ00254
Location:1 → 252

PTZ00254; 40S ribosomal protein SA; Provisional