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Pla1a phospholipase A1 member A [ Rattus norvegicus (Norway rat) ]

Gene ID: 85311, updated on 4-Jan-2025

Summary

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Official Symbol
Pla1aprovided by RGD
Official Full Name
phospholipase A1 member Aprovided by RGD
Primary source
RGD:621261
See related
EnsemblRapid:ENSRNOG00000057153 AllianceGenome:RGD:621261
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pspla1; Ps-pla1
Summary
Predicted to enable phospholipase A1 activity. Predicted to be involved in lipid catabolic process. Predicted to be located in acrosomal membrane. Predicted to be active in extracellular space. Orthologous to human PLA1A (phospholipase A1 member A). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 302.9), Heart (RPKM 91.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pla1a in Genome Data Viewer
Location:
11q21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (75825626..75863296)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (62320112..62357779)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (64882024..64919714)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352341 Neighboring gene ADP-ribosylarginine hydrolase Neighboring gene popeye domain cAMP effector 2 Neighboring gene cytochrome c oxidase copper chaperone COX17 Neighboring gene cilia and flagella associated protein 91

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phosphatidylserine-specific phospholipase A1 stimulates histamine release from rat peritoneal mast cells through production of 2-acyl-1-lysophosphatidylserine. Hosono H, et al. J Biol Chem, 2001 Aug 10. PMID 11395520
  2. Serine phospholipid-specific phospholipase A that is secreted from activated platelets. A new member of the lipase family. Sato T, et al. J Biol Chem, 1997 Jan 24. PMID 8999922
  3. Phospholipase B is activated in response to sterol removal and stimulates acrosome exocytosis in murine sperm. Asano A, et al. J Biol Chem, 2013 Sep 27. PMID 23943622, Free PMC Article
  4. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Abonnenc M, et al. Circ Res, 2013 Oct 25. PMID 24006456
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phospholipase A1 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase A1 activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in acrosomal membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phospholipase A1 member A
Names
phosphatidylserine-specific phospholipase A1
NP_620237.1
XP_006248439.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138882.2 → NP_620237.1  phospholipase A1 member A precursor

    See identical proteins and their annotated locations for NP_620237.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/Swiss-Prot
    P97535
    UniProtKB/TrEMBL
    A6IR69
    Related
    ENSRNOP00000071860.1, ENSRNOT00000077727.3
    Conserved Domains (1) summary
    pfam00151
    Location:14 → 336
    Lipase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    75825626..75863296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248377.4 → XP_006248439.1  phospholipase A1 member A isoform X1

    Related
    ENSRNOP00000108165.1, ENSRNOT00000127091.1
    Conserved Domains (2) summary
    cd00707
    Location:49 → 332
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    pfam00151
    Location:14 → 336
    Lipase; Lipase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97535.1 GenPept UniProtKB/Swiss-Prot:P97535

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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