U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PTI1 cleavage polyadenylation factor subunit PTI1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853060, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
PTI1
Official Full Name
cleavage polyadenylation factor subunit PTI1
Primary source
SGD:S000003388
Locus tag
YGR156W
See related
AllianceGenome:SGD:S000003388; FungiDB:YGR156W; VEuPathDB:YGR156W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable mRNA binding activity. Predicted to contribute to RNA binding activity. Involved in mRNA processing; sno(s)RNA 3'-end processing; and termination of RNA polymerase II transcription, exosome-dependent. Located in cytosol and nucleus. Part of mRNA cleavage and polyadenylation specificity factor complex. [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PTI1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (800546..801823)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene omega-class glutathione transferase Neighboring gene cystathionine beta-synthase CYS4 Neighboring gene phosphatidylethanolamine N-methyltransferase Neighboring gene exosome non-catalytic core subunit MTR3

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Pti1p and Ref2p found in association with the mRNA 3' end formation complex direct snoRNA maturation. Dheur S, et al. EMBO J, 2003 Jun 2. PMID 12773397, Free PMC Article
  2. The RNA polymerase II CTD kinase CTDK-I affects pre-mRNA 3' cleavage/polyadenylation through the processing component Pti1p. Skaar DA, et al. Mol Cell, 2002 Dec. PMID 12504017
  3. Regulation of yeast mRNA 3' end processing by phosphorylation. He X, et al. Mol Cell, 2005 Sep 2. PMID 16137619
  4. The essential N terminus of the Pta1 scaffold protein is required for snoRNA transcription termination and Ssu72 function but is dispensable for pre-mRNA 3'-end processing. Ghazy MA, et al. Mol Cell Biol, 2009 Apr. PMID 19188448, Free PMC Article
  5. Dynamics in Fip1 regulate eukaryotic mRNA 3' end processing. Kumar A, et al. Genes Dev, 2021 Nov 1. PMID 34593603, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to RNA binding IC
Inferred by Curator
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sno(s)RNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in termination of RNA polymerase II transcription, exosome-dependent IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mRNA cleavage and polyadenylation specificity factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mRNA cleavage and polyadenylation specificity factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
cleavage polyadenylation factor subunit PTI1
NP_011672.1
  • Essential component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; relocalizes to the cytosol in response to hypoxia; similar to mammalian Cleavage-Stimulation Factor CstF-64

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    800546..801823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181285.1 → NP_011672.1  TPA: cleavage polyadenylation factor subunit PTI1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011672.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUT6, P39927
    UniProtKB/TrEMBL
    A6ZUG7, B3LI74, B5VJ99, C7GQ64, C8Z950, G2WEN6, N1P3T5
    Conserved Domains (3) summary
    TIGR01628
    Location:306 → 413
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    smart00360
    Location:21 → 90
    RRM; RNA recognition motif
    pfam14327
    Location:185 → 255
    CSTF2_hinge; Hinge domain of cleavage stimulation factor subunit 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39927.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools