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GID10 Gid10p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852957, updated on 4-Jan-2025

Summary

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Official Symbol
GID10
Official Full Name
Gid10p
Primary source
SGD:S000003298
Locus tag
YGR066C
See related
AllianceGenome:SGD:S000003298; FungiDB:YGR066C; VEuPathDB:YGR066C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in protein catabolic process; response to osmotic stress; and response to starvation. Part of GID complex. Orthologous to human GID4 (GID complex subunit 4 homolog). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See GID10 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (620921..621799, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene transcription elongation factor SPT4 Neighboring gene Vht1p Neighboring gene uncharacterized protein Neighboring gene Art5p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure of yeast Gid10 in complex with Pro/N-degron. Shin JS, et al. Biochem Biophys Res Commun, 2021 Dec 10. PMID 34695755
  2. Vid24p, a novel protein localized to the fructose-1, 6-bisphosphatase-containing vesicles, regulates targeting of fructose-1,6-bisphosphatase from the vesicles to the vacuole for degradation. Chiang MC, et al. J Cell Biol, 1998 Mar 23. PMID 9508768, Free PMC Article
  3. Gid10 as an alternative N-recognin of the Pro/N-degron pathway. Melnykov A, et al. Proc Natl Acad Sci U S A, 2019 Aug 6. PMID 31337681, Free PMC Article
  4. A GID E3 ligase assembly ubiquitinates an Rsp5 E3 adaptor and regulates plasma membrane transporters. Langlois CR, et al. EMBO Rep, 2022 Jun 7. PMID 35437932, Free PMC Article
  5. Defining the specificity of cotranslationally acting chaperones by systematic analysis of mRNAs associated with ribosome-nascent chain complexes. del Alamo M, et al. PLoS Biol, 2011 Jul. PMID 21765803, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crystal structure of yeast Gid10 in complex with Pro/N-degron.
    Title: Crystal structure of yeast Gid10 in complex with Pro/N-degron.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein catabolic process in the vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to osmotic stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to starvation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of GID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GID complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Gid10p
NP_011580.3
  • Recognition component (N-recognin) of the Pro/N-degron pathway; recognizes and targets for degradation proteins with N-terminal degradation signals; expressed only under starvation or osmotic stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    620921..621799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181195.3 → NP_011580.3  TPA: Gid10p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011580.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUK0, P53242, Q45U21, Q6B2W2
    UniProtKB/TrEMBL
    A6ZV50, B3LIF8, C7GXP8, C8Z8W0, G2WEF2, N1P260
    Conserved Domains (1) summary
    COG5073
    Location:1 → 288
    VID24; Vacuolar import and degradation protein [Intracellular trafficking and secretion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53242.1

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