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MPO1 Mpo1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852874, updated on 4-Jan-2025

Summary

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Official Symbol
MPO1
Official Full Name
Mpo1p
Primary source
SGD:S000002978
Locus tag
YGL010W
See related
AllianceGenome:SGD:S000002978; FungiDB:YGL010W; VEuPathDB:YGL010W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables fatty acid alpha-dioxygenase activity. Involved in fatty acid alpha-oxidation and sphingoid catabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See MPO1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (475545..476069)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene delta(24(24(1)))-sterol reductase Neighboring gene proteasome core particle subunit alpha 1 Neighboring gene 3-isopropylmalate dehydratase LEU1 Neighboring gene H(+)-exporting P2-type ATPase PMA1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Catalytic residues, substrate specificity, and role in carbon starvation of the 2-hydroxy FA dioxygenase Mpo1 in yeast. Mori K, et al. J Lipid Res, 2020 Jul. PMID 32350077, Free PMC Article
  2. Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids. Kondo N, et al. Nat Commun, 2014 Oct 27. PMID 25345524
  3. Saccharomyces cerevisiae S288C genome annotation: a working hypothesis. Fisk DG, et al. Yeast, 2006 Sep. PMID 17001629, Free PMC Article
  4. The S. cerevisiae m6A-reader Pho92 promotes timely meiotic recombination by controlling key methylated transcripts. Scutenaire J, et al. Nucleic Acids Res, 2023 Jan 25. PMID 35934316, Free PMC Article
  5. Yeast Mpo1 Is a Novel Dioxygenase That Catalyzes the α-Oxidation of a 2-Hydroxy Fatty Acid in an Fe(2+)-Dependent Manner. Seki N, et al. Mol Cell Biol, 2019 Mar 1. PMID 30530523, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acid alpha-dioxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid alpha-oxidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sphingoid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingoid catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mpo1p
NP_011505.1
  • Dioxygenase that catalyzes alpha-oxygenation of 2-hydroxy fatty acids; involved in metabolism of phytosphingosine; not an essential gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    475545..476069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180875.1 → NP_011505.1  TPA: Mpo1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011505.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUC7, P25338
    UniProtKB/TrEMBL
    A6ZUY3, B3LIM5, B5VIV3, C7GK63, C8Z8N3, G2WE83, N1P206
    Conserved Domains (1) summary
    COG4539
    Location:5 → 174
    COG4539; Uncharacterized membrane protein YGL010W [Function unknown]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25338.2

Gene LinkOut

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