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DUO1 Duo1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852819, updated on 4-Jan-2025

Summary

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Official Symbol
DUO1
Official Full Name
Duo1p
Primary source
SGD:S000003029
Locus tag
YGL061C
See related
AllianceGenome:SGD:S000003029; FungiDB:YGL061C; VEuPathDB:YGL061C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to microtubule plus-end binding activity. Involved in attachment of spindle microtubules to kinetochore; positive regulation of attachment of spindle microtubules to kinetochore; and positive regulation of microtubule polymerization. Part of DASH complex. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See DUO1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (388968..389711, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene pseudouridine synthase PUS2 Neighboring gene pyruvate carboxylase 1 Neighboring gene Ybp2p Neighboring gene protein kinase PKP2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation. Kang J, et al. J Cell Biol, 2001 Nov 26. PMID 11724818, Free PMC Article
  2. Exhaustive identification of interaction domains using a high-throughput method based on two-hybrid screening and PCR-convergence: molecular dissection of a kinetochore subunit Spc34p. Ikeuchi A, et al. Nucleic Acids Res, 2003 Dec 1. PMID 14627828, Free PMC Article
  3. Nsl1p is essential for the establishment of bipolarity and the localization of the Dam-Duo complex. Scharfenberger M, et al. EMBO J, 2003 Dec 15. PMID 14657030, Free PMC Article
  4. Saccharomyces cerevisiae Duo1p and Dam1p, novel proteins involved in mitotic spindle function. Hofmann C, et al. J Cell Biol, 1998 Nov 16. PMID 9817759, Free PMC Article
  5. Kinetochore-microtubule error correction is driven by differentially regulated interaction modes. Kalantzaki M, et al. Nat Cell Biol, 2015 Apr. PMID 25751138, Free PMC Article

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to microtubule plus-end binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in attachment of spindle microtubules to kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of attachment of spindle microtubules to kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of microtubule polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of DASH complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DASH complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of DASH complex IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Duo1p
NP_011454.1
  • Essential subunit of the Dam1 complex (aka DASH complex); cooperates with Dam1p and Pse1p to connect the DASH complex with microtubules (MT); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    388968..389711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180926.1 → NP_011454.1  TPA: Duo1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011454.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU80, P53168
    UniProtKB/TrEMBL
    A6ZUB5, C7GRJ7, G2WE35, N1P9R3
    Conserved Domains (1) summary
    pfam08651
    Location:63 → 135
    DASH_Duo1; DASH complex subunit Duo1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53168.1

Gene LinkOut

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