Mpp2 MAGUK p55 scaffold protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mpp2provided by RGD
Official Full Name: MAGUK p55 scaffold protein 2provided by RGD
Primary source: RGD:620014
See related: EnsemblRapid:ENSRNOG00000059683 AllianceGenome:RGD:620014
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dlg2
Summary: Enables PDZ domain binding activity. A structural constituent of postsynaptic density. Involved in protein homooligomerization. Located in postsynaptic density. Is active in glutamatergic synapse. Orthologous to human MPP2 (MAGUK p55 scaffold protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 63.4), Lung (RPKM 14.4) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (87511638..87544710, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (87011434..87043883, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (89998284..90030766, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Behavioural and molecular characterisation of the Dlg2 haploinsufficiency rat model of genetic risk for psychiatric disorder.
Title: Behavioural and molecular characterisation of the Dlg2 haploinsufficiency rat model of genetic risk for psychiatric disorder.
proteins. Our results highlight a previously unexplored role for MPP2 at postsynaptic sites as a scaffold that links SynCAM1 cell adhesion molecules to core proteins of the postsynaptic density.
Title: MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1 cell adhesion molecules to core components of the postsynaptic density.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH134320 (e-PCR)
- UniSTS:217602

BE112030 (e-PCR)
- UniSTS:246058

RH137648 (e-PCR)
- UniSTS:219735

BE119088 (e-PCR)
- UniSTS:249084

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of postsynaptic density	IEA Inferred from Electronic Annotation more info
enables structural constituent of postsynaptic density	IMP Inferred from Mutant Phenotype more info	PubMed
enables structural constituent of postsynaptic density	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in maintenance of postsynaptic density structure	IEA Inferred from Electronic Annotation more info
involved_in protein homooligomerization	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite membrane	IEA Inferred from Electronic Annotation more info
located_in dendrite membrane	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	IEA Inferred from Electronic Annotation more info
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: MAGUK p55 subfamily member 2

Names: membrane palmitoylated protein 2; membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001414214.1 → NP_001401143.1 MAGUK p55 subfamily member 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

D3ZAA9, G3V8T8

Related

ENSRNOP00000072422.2, ENSRNOT00000092150.3
NM_001414222.1 → NP_001401151.1 MAGUK p55 subfamily member 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

D3ZAA9, G3V8T8
NM_053513.2 → NP_445965.1 MAGUK p55 subfamily member 2

See identical proteins and their annotated locations for NP_445965.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

D3ZAA9, G3V8T8

Related

ENSRNOP00000073193.3, ENSRNOT00000090456.3

Conserved Domains (5) summary

smart00569
Location:13 → 66

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12037
Location:229 → 287

SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)

smart00072
Location:359 → 540

GuKc; Guanylate kinase homologues

cd00992
Location:138 → 216

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02828
Location:68 → 119

L27; L27 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

87511638..87544710 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063270001.1 → XP_063126071.1 MAGUK p55 subfamily member 2 isoform X2

UniProtKB/Swiss-Prot

D3ZAA9, G3V8T8
XM_063270002.1 → XP_063126072.1 MAGUK p55 subfamily member 2 isoform X2

UniProtKB/Swiss-Prot

D3ZAA9, G3V8T8
XM_008768128.3 → XP_008766350.1 MAGUK p55 subfamily member 2 isoform X1

See identical proteins and their annotated locations for XP_008766350.1

UniProtKB/TrEMBL

A0A8L2R7D6

Related

ENSRNOP00000101144.1, ENSRNOT00000161854.1

Conserved Domains (6) summary

smart00569
Location:30 → 83

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12037
Location:246 → 304

SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)

smart00072
Location:376 → 557

GuKc; Guanylate kinase homologues

cd00992
Location:155 → 233

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:366 → 556

Guanylate_kin; Guanylate kinase

pfam02828
Location:85 → 136

L27; L27 domain