Abcg1 ATP binding cassette subfamily G member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abcg1provided by RGD
Official Full Name: ATP binding cassette subfamily G member 1provided by RGD
Primary source: RGD:620294
See related: EnsemblRapid:ENSRNOG00000001158 AllianceGenome:RGD:620294
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Abc8
Summary: Predicted to enable several functions, including ABC-type sterol transporter activity; adenyl ribonucleotide binding activity; and protein dimerization activity. Involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus and positive regulation of secretory granule organization. Predicted to be located in external side of plasma membrane; mitochondrion; and recycling endosome. Predicted to be active in plasma membrane. Biomarker of end stage renal disease. Orthologous to human ABCG1 (ATP binding cassette subfamily G member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 207.9), Spleen (RPKM 182.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (9128056..9184312)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (9126687..9182948)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (9743269..9842735)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decreased expression of ATP-binding cassette protein G1 promotes abnormal adipogenesis of condylar chondrocytes in temporomandibular joint osteoarthritis.
Title: Decreased expression of ATP-binding cassette protein G1 promotes abnormal adipogenesis of condylar chondrocytes in temporomandibular joint osteoarthritis.
Deregulation of ABCG1 early in life contributes to prostate carcinogenesis in maternally malnourished offspring rats.
Title: Deregulation of ABCG1 early in life contributes to prostate carcinogenesis in maternally malnourished offspring rats.
ABCG1 and ABCG4 as key transporters in the development of pulmonary alveolar proteinosis by nanoparticles.
Title: ABCG1 and ABCG4 as key transporters in the development of pulmonary alveolar proteinosis by nanoparticles.
The addition of U0126 resulted in a marked reduction of lipid deposition, upregulation of ABCA1/G1 expression and suppression of CD36 expression in Ox-LDL-stimulated macrophages.
Title: Inhibition of ERK1/2 improves lipid balance in rat macrophages via ABCA1/G1 and CD36.
ABCA1 is diminished and ABCG1 is increased by N-acetylcysteine, which counteracts the reduction in apo A-I-mediated cholesterol efflux
Title: N-acetylcysteine prevents endoplasmic reticulum stress elicited in macrophages by serum albumin drawn from chronic kidney disease rats and selectively affects lipid transporters, ABCA-1 and ABCG-1.
ABCG1 is involved in cellular vitamin E efflux.
Title: ABCG1 is involved in vitamin E efflux.
enriched in chronic inflammation of the small intestine of type 2 diabetic rats
Title: ABCA1 and ABCG1 expression in the small intestine of type 2 diabetic rats.
In macrophages under oxidative stress (by overloading with oxidized LDL), down-regulation of ABCG-1 and ABCA-1 is key to regulation of metabolism of 7-ketocholesterol and other sterols.
Title: Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1.
Endothelin-1 markedly decreased ABCG1 levels via endothelin type A and B receptors and activation of the phosphatidylinositol 3-kinase pathway. Endothelin-1 may have also enhanced ABCG1's degradation.
Title: Endothelin-1 exacerbates lipid accumulation by increasing the protein degradation of the ATP-binding cassette transporter G1 in macrophages.
LpE and LRP1 promote axonal extension, and suggest that lipids exported to LpE by ABCG1 are important for the enhancement of axonal extension mediated by LpE.
Title: Involvement of low-density lipoprotein receptor-related protein and ABCG1 in stimulation of axonal extension by apoE-containing lipoproteins.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH141020 (e-PCR)
- UniSTS:223020

BE119023 (e-PCR)
- UniSTS:249074

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ABC-type sterol transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ABC-type sterol transporter activity	ISO Inferred from Sequence Orthology more info
enables ADP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables cholesterol transfer activity	ISO Inferred from Sequence Orthology more info
enables floppase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine floppase activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables toxin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to high density lipoprotein particle stimulus	ISO Inferred from Sequence Orthology more info
involved_in cholesterol efflux	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in cholesterol transport	TAS Traceable Author Statement more info	PubMed
involved_in glycoprotein transport	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in intracellular cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in lipid translocation	IEA Inferred from Electronic Annotation more info
involved_in low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid storage	ISO Inferred from Sequence Orthology more info
involved_in phospholipid efflux	ISO Inferred from Sequence Orthology more info
involved_in phospholipid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of secretory granule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to lipid	ISO Inferred from Sequence Orthology more info
involved_in reverse cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP-binding cassette sub-family G member 1

Names: ATP-binding cassette, sub-family G (WHITE), member 1; ATP-binding cassette, subfamily G (WHITE), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053502.2 → NP_445954.2 ATP-binding cassette sub-family G member 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

A6JJX9, G3V642, Q9EPG9

Related

ENSRNOP00000074901.3, ENSRNOT00000078031.3

Conserved Domains (1) summary

TIGR00955
Location:60 → 666

3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein